Background: Systemic Lupus Erythematosus (SLE) is an autoimmune disorder which affects multiple organs of human including lungs. Objectives: in SLE patients and to correlate them with the duration of the disease. Method: This cross-sectional study was carried out in the Department of Physiology, BSMMU, Dhaka, from January 2010 to December 2010. A total number of 120 female subjects were selected, among which 30 were age and BMI matched apparently healthy subjects for comparison (control) and 90 were patients of SLE (study group). All the patients were matched for age, sex and BMI. Based on the duration of the disease, patients were subdivided into B1 (1-6 months), B2 (2-5 years) and B3 (6-10 years). Controls were selected from the community and the patients from the Out Patient Department (OPD) of SLE clinic, Department of Medicine, BSMMU, Dhaka. (PEFR) and FEF 25-75 of all the subjects were measured by a Digital MicroDL spirometer. For statistical analysis Independent Sample 't' test, One way ANOVA test and Pearson's correlation coefficient test were performed as applicable. Results: The mean percentage of predicted values of lung function parameters in healthy female subjects were within normal ranges. The mean percentage of predicted values of PEFR and FEF 25-75 were significantly lower in all study groups when compared to control. Again, the mean percentage of predicted values of PEFR and FEF 25-75 were significantly lower in the patients of Group B3 compared to Group B2. Moreover, these comparisons were significantly lower when compared to Group B1. The differences of the mean percentage of predicted value of PEFR, FEF 25-75 were non-significantly lower in Group B2 when compare to Group B1. In addition, FEF 25-75 were positively correlated with duration of SLE in group B2 but negatively correlated in B3. On the other hand PEFR was negatively correlated with duration of SLE in both B2 and B3. All these values were statistically non-significant. Conclusion: These pulmonary functions decrease in SLE female and the reduction is inconsistently associated with duration of the disease.
The aim of the observational case control study was to find out the association of type 2 diabetes mellitus (T2DM) with serum adiponectin level in Bangladeshi population. This was conducted in the Biomedical Research Group, Research Division, Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic Disorders (BIRDEM), Dhaka, Bangladesh. Sixty six T2DM subjects and seventy four healthy control subjects were included. Diabetes was diagnosed and classified as per World Health Organization criteria. Serum adiponectin was measured by Enzyme Linked Immunosorbent Assay (ELISA) method. Serum glucose was measured by glucose-oxidase method; serum insulin was measured by chemiluminescence- based ELISA technique. The insulin secretory capacity (HOMA%B), insulin sensitivity (HOMA%S) & insulin resistance (HOMA-IR) were assayed by homeostasis model assessment method. Statistical analysis was performed using SPSS Windows version 11.5. The median (range) fasting serum insulin of control and T2DM subjects were 14.7 (1.9-45.9) and 18.1 (4.1-42.8), respectively. The median (range) serum adiponectin (?g/ml) of the control and T2DM subjects were 8.7 (0.8-16.0) and 6.2 (1.1-22.4). The serum adiponectin of T2DM was significantly lower than the control subjects (p < 0.001). The median (range) HOMA%B values of control and T2DM subjects were 160.1 (33.4-493.4) and 100.5 (17.7-349.3), respectively. The median HOMA%B of T2DM subjects was significantly lower than the control subjects (p < 0.001). The median (range) HOMA%S values of control and T2DM subjects were 44.2 (9.8-339.4) and 32.8 (14.3-154.7), respectively. The median HOMA%S of T2DM group was significantly lower than the control subjects (p < 0.05). The median (range) HOMA-IR of control and T2DM subjects were 3.5 (0.5-11.4) and 5.8 (1.0-28.3), respectively. The median HOMA-IR of T2DM subjects was significantly higher than the control subjects (p < 0.001). The results of the study suggest that T2DM subjects have both insulin secretory defects, insulin resistance and associated with lower serum adiponectin level in Bangladeshi population.Mediscope Vol. 2, No. 2: July 2015, Pages 16-21
Ovary is one of the essential reproductive organs in human being. A detailed histomorphological feature of ovary is an un-debatable for diagnostic and therapeutic purpose for ovarian disease. The standardization of the morphological and histological measurements of ovary in general in Bangladeshi people is essential to increase the knowledge regarding anatomical variation in our population. So a research work on detailed anatomical parameters of ovary is an un-debatable. Objective: To find out the follicles in different age groups post mortem human ovary. Methodology: The cross-sectional observational study was carried out in the Department of Anatomy, Sylhet MAG Osmani Medical College, Sylhet in collaboration with the Department of Forensic Medicine, Sylhet MAG Osmani Medical College during the period from January 2016 to December 2016. Sixty pairs of human postmortem ovaries were collected. The inclusion criteria were dead bodies autopsied within 36 hours of death. Considerable signs of decomposition or decomposed dead body, presence of gross ovarian disease and any history of poisoning cases were excluded. All the specimens were examined for morphological parameters but only 18 specimens were examined histological parameters. Results: The highest total numbers of the follicles were found in the age group A and lowest total numbers of the follicles were in the age group C. The differences of total numbers of the follicles were significant between group-A and group-B (p<0.001); and group-A and group-C (p<0.001); but no significant difference was observed between group-B and group-C (p=0.080). Conclusion: Histomorphologically, the total number of the follicles is found maximum at reproductive years and is declined through perimenopause and postmenopause. Central Medical College Journal Vol 5 No 2 Jul 2021 PP 84-87
Background: The physiological role of adiponectin is not yet fully clear, but it is now generally accepted that it has a protective role against the development of lifestyle disorders, related to insulin resistance and atherosclerosis. Insulin resistance is one of the basic defects of type 2 diabetes (T2DM) and adiponectin is inversely associated with T2DM. As serum adiponectin level has not yet been investigated in Bangladeshi T2DM subjects,so that the present study has been under taken to find out the association of T2DM with serum adiponectin level in Bangladeshi population.Methodology: In this observational case control study, sixty six (66) T2DM subjects, seventy four (74) healthy control subjects were included. Diabetes was diagnosed and classified as per WHO criteria. Serum Adiponectin was measured by Enzyme Linked Immunosorbent Assay (ELISA) method. Serum glucose was measured by glucose-oxidase method; serum insulin was measured by chemiluminescence-based ELISA technique. The insulin secretory capacity (HOMA%B), insulin sensitivity (HOMA%S) & insulin resistance (HOMA IR) were assayed by homeostasis model assessment method.Results: The study subjects were BMI matched. BMI of the Control subjects and T2DM subjects (Mean±SD) were 25.02±3.55 and 25.85±3.62. Age (year) of the Control subjects and T2DM subjects (Mean±SD) were 42.46±9.24 and 48.49±8.09. Median (range) fasting serum insulin in the control and T2DM was 14.68 (1.86-45.92) and 18.09 (4.10-42.78) respectively which was not statistically significant (p=0.214). Median (range) HOMA%B values in the control and T2DM subjects was 160.10(33.40-493.40) and 100.45(17.70-349.30). Median HOMA%B in the T2DM group was significantly lower compared to the control (p=0.0001). Median (range) HOMA%S values in the control and T2DM subjects was 44.20(9.80- 339.40) and 32.80(14.30-154.70) respectively. Median HOMA%S in the T2DM group was significantly lower compared to the control (p=0.036). Median (range) serum adiponectin (?g/ml) of the control and T2DM subjects was 8.70 (0.76-15.96) and 6.19 (1.13-22.37). Serum adiponectin was significantly lower in T2DM compared to the control (p=0.0001).Conclusions: From this study it may be concluded that, T2DM subjects have both insulin secretory defects and insulin resistance and associated with lower serum adiponectin level in Bangladeshi population.Anwer Khan Modern Medical College Journal Vol. 6, No. 1: January 2015, Pages 10-13
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