Medicinal plants have been used for treating many kinds of illness due to their safety, cheap and easy to be accessed by all level of society. This study was aimed to determine the effect of the dosage forms (fresh, boiled and ethanol extracted) and the duration (24 and 42 days) of medicinal plant Centella asiatica to the levels of superoxide dismutase (SOD), malondialdehyde (MDA) and the histopathology of diabetic rat brain. The results showed that administration of various dosage forms of C. asiatica were able to increase the number of pyramid cells and neuroglia in the cerebrum significantly (P <0.01) but had no significant effect (P>0.01) at the administration length and the interaction between both treatments. This finding resulted in the new traditional herbal medicine that can be used for treating degenerative disorders on nervous system.
Antifertility agents with safety and effectiveness in terms of minimum side effects have always been a subject of debate. Many studies have been conducted on plants to observe the antifertility effect, but majority of them were toxic. Centella asiatica and Plucea indica leaves have been traditionally used as medicine for its properties to promote antifertility effect. The objective of the present study was to investigate the combination effects of C. asiatica and P. indica leaf extract to the number of follicles, antioxidant activity, and hormonal profile of female rats. Thirty two fertile female rats (2 months), were divided into six groups and treated with different formula of the combination of C. asiatica and P. indica leaf extract: group 1 (T1) with 25 + 25 mg/kg bw, group 2 (T2) with 50 + 50 mg/kg bw, group 3 (T3) with 75 + 75 mg/kg bw, group 4 (T4) with 125 + 125 mg/kg bw, (T5) group 5 with 200 + 200 mg/kg bw, and control group (T0) treated with only 0,5% Na CMC. They were also fed for 42 days. The rat's blood serum was taken for hormonal analysis, as well they were sacrificed and the ovarium were removed for histological and antioxidant analysis. The results revealed that C. asiatica and P. indica leaf extract influences to the number of follicles, antioxidant activity and hormonal profile of the rats. Group 4 (T4) showed the highest antifertility effect on the ovulation number (corpus lutium), total of ovarian follicles, and level of estrogen, respectively. Group 5 (T5) showed the highes level of superoxide dismutase (SOD) and the lowest level of Malondialdehide (MDA). It is concluded that C. asiatica and P. indica exhibited antifertility effects on reproductive system of the female rats.
<span>Candidiasis is one disease that has experienced</span><span lang="IN"> by </span><span>75% </span><span lang="IN">of </span><span>women in Indonesia caused by fungal infection</span><span lang="IN">,</span><em><span>Candida albicans</span></em><span>. Candidiasis can cause serious complications such as infertility. One of the best known ingredients to cure infertility problems is jeringau rhizome (<em>Acorus</em></span><em><span>calamus</span></em><span> L.). This research is the first step to process</span><span lang="IN"> for <span><ins datetime="2018-05-29T04:08"><span><span style="text-decoration: underline;"><span style="color: #008080;"> </span></span></span></ins></span></span><span>standardization and scientification</span><span lang="IN"> of </span><span>jeringau</span><span lang="IN"> rizhome </span><span>as one of the basic ingredients of</span><span lang="IN"> Madura</span><span> traditional medicine</span><span lang="IN">, jamu</span><span> "Subur</span><span>Kandungan". </span><span lang="IN">It was aimed to investigate antioxidant and antifungal activity of jeringau rizhome in some organic solvents.</span><span> Samples were extracted by maceration method using ethanol, chloroform</span><span lang="IN">,</span><span> and n-hexane. Antioxidant</span><span lang="IN"> activity</span><span lang="IN">assay</span><span lang="IN">was determined </span><span>using DPPH method</span><span lang="IN">.</span><span lang="IN">Ascorbic acid was used as control. </span><span lang="IN"><span> </span></span><span>Antifungal activity test on <em>Candida albicans</em> </span><span lang="IN">was done by using</span><span lang="IN">kirby bauer method to measure diameter of inhibition zone and microdilution plate method to determine MIC and MFC.</span><span> The highest antioxidant </span><span lang="IN">activity was revealed by ethanol</span><span lang="IN">followed by chloroform and n-hexane, while the highest antifungal activity was obtained by ethanol followed by n-hexane and chloroform. </span><span>The MIC value of </span><span lang="IN">ethanol, chloroform and n-hexane</span><span>were founded at concentration of 0.39% and the MFC at a concentration of 0.78%.</span>
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