Dosage and Administration Length of Centella Asiatica (L.) Urban Decrease the Level of Sod and Mda and Improve Brain Histological Condition of Rats

Abstract

Medicinal plants have been used for treating many kinds of illness due to their safety, cheap and easy to be accessed by all level of society. This study was aimed to determine the effect of the dosage forms (fresh, boiled and ethanol extracted) and the duration (24 and 42 days) of medicinal plant Centella asiatica to the levels of superoxide dismutase (SOD), malondialdehyde (MDA) and the histopathology of diabetic rat brain. The results showed that administration of various dosage forms of C. asiatica were able to increase the number of pyramid cells and neuroglia in the cerebrum significantly (P <0.01) but had no significant effect (P>0.01) at the administration length and the interaction between both treatments. This finding resulted in the new traditional herbal medicine that can be used for treating degenerative disorders on nervous system.

Antifertility Effect of Centella asiatica (L) Urban and Plucea indica (L) Urban on the Number of Follicles, Antioxidant Activity and Hormonal Profile of White Rat's Ovaries

“…The procedure for the extraction of C. gigantea leaves referred to the procedure previously described by Muchtaromah et al (2016) on Centella asiatica leaves. This study employed an experimental design using a completely randomized design (CRD).Thirty two fertile female rats (2 months), were divided into six groups and treated with different formula of the combination of C. asiatica and P. indica leaf extract: group 1 (T1) with 25 + 25 mg/kg bw, group 2 (T2) with 50 + 50 mg/kg bw, group 3 (T3) with 75 + 75 mg/kg bw, group 4 (T4) with 125 + 125 mg/kg bw, group 5 (T5) with 200 + 200 mg/kg bw, and control group (C) treated with only 0,5% Na CMC.…”

Centella asiatica (L.) Urb. Prevents Hypertension and Protects the Heart in Chronic Nitric Oxide Deficiency Rat Model

“…Asiatic acid, another bioactive compound in C. asiatica , had been shown to exert significant anti-hypertensive effect in numerous types of hypertensive rat model ( Bunbupha et al, 2014 ; Maneesai et al, 2016a ; Maneesai et al, 2017 ). The ethanolic extract was also reported to possess cardioprotective benefit in myocardial infarction ( Pragada et al, 2004 ) in addition to its high antioxidant activities ( Muchtaromah et al, 2016 ). Nevertheless, we could not find any literature on the cardioprotective ability of C. asiatica extracted using other methods.…”

“…We only used a single dose of ethanolic extract of C. asiatica , guided from the results of our pilot study using three different doses; 300, 500 and 1,000 mg/kg ( Supplementary Material ). At the dose of 300 mg/kg, C. asiatica was reported to have high anti-oxidant properties ( Muchtaromah et al, 2016 ) and at the dose of 500 mg/kg, this extract possessed significant diuretic property ( Roopesh et al, 2011 ) which had the potential as an anti-hypertensive agent. Meanwhile, C. asiatica at the dose of 1,000 mg/kg exhibited a significant reduction in the ischemic area of cardiac tissues in rat model with post-myocardial infarction event ( Pragada et al, 2004 ).…”

Antibacterial activity of water and ethanol extract of Allium sativum, Curcuma mangga, and Acorus calamus combination

“…The procedure for the water and ethanol extraction of garlic, temu mangga and jeringau referred to the procedure on Centella asiatica which was previously described by (Muchtaromah et al, 2011;Muchtaromah, et al, 2016). 50 g of mix powder of garlic, temu mangga and jeringau was added to 200 mL of ethanol soaked for 24 h, homogenized for 3 h, and filtered with a whatman filter paper grade 1 (Sigma aldrich) on funnel Buchner.…”