Objective: The aim of the study was to evaluate the effect of 4 μg/kg teriparatide administered at intermittent and continuous frequencies on bone formation in the expanded midpalatal suture region using histomorphometric and micro-computed tomography (micro-Ct) analysis. Settings and sample population: In this study, 24 Sprague Dawley male rats were used.
Methods:The experimental animals were divided into 3 groups as follows: Group 1: only maxillary expansion, Group 2: maxillary expansion with continuous teriparatide administration (2 μg in the morning and 2 μg in the evening) and Group 3: maxillary expansion with intermittent teriparatide administration (daily 4 μg/kg). The expansion appliance was fixed to maxillary incisors of all animals within the 5-day expansion period, followed by a 12-day retention phase. Animals were sacrificed at the end of the retention period, and specimens were evaluated by micro-Ct and histomorphometric analysis respectively.
Results:The results of the histomorphometric analysis showed that Group 3 had the highest number of osteoblasts (1042 ± 90.76) (P < .01). In addition, the results of micro-Ct analysis revealed that Group 3 had the highest bone volume/total volume (16% ± 0), bone mineral density (173.82 ± 2.6 mgHA/cm 3 ) and least midpalatal suture width (0.13 ± 0.001 mm) (P < .01). Osteoblasts number and micro-Ct analysis values of Group 2 were higher than those of Group 1 but no significant differences between them (P > .01).
Conclusion:Intermittently administered TP (4 μg/kg once a day) was seen to enhance bone formation and mineralization. In the future, it can be used in drug studies that will increase or stimulate bone formation as well as in the midpalatal suture area. How to cite this article: Koca CG, Sadry S, Asker H, Çiçek MF, Kösehasanoğulları M, Kaya G. Effects of the different administration frequencies of teriparatide (PTH [1-34]) on new bone formation of expanded midpalatal sutures in rats: A histomorphometric and micro-computed tomography analysis.
Objectives:
The position of the inferior alveolar canal (IAC) and its course in the mandible
is crucial to prevent complications in oral surgical procedures. Therefore, the present study aims to
predict the course of IAC using landmarks specific to the mandible and to correlate with cone-beam
computed tomography images.
Methods:
On the included panoramic radiographs (n=529), the closest point of the IAC to the inferior
border of the mandible (Q) was determined, and the distances of this point to the mental (Mef) and
mandibular foramen (Maf) were measured in millimeters. To determine the buccolingual course of the
IAC on CBCT images (n=529), the distances from the center of the canal to the buccal and lingual
cortices and between the cortices were measured at the level of the root apices of the first and second
premolars and molars. Also, the positions of the Mef to adjacent premolars and molars were classified.
Results:
The most common position of mental foramen was Type-3 (37.1%). On the coronal plane, it
was also observed that as the Q point approaches the Mef, the IAC is located in the mandible's center
at the second premolar level (p=0.008) and moves away from the midline at the level of the first molar
(p=0.007).
Conclusions:
Based on the results, a correlation was observed between the horizontal course of the
IAC and its proximity to the inferior border of the mandible. Therefore, the curvature of the IAC and
its proximity to the mental foramen should be considered in oral surgeries.
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