ABSTRACT… Introduction:The doctors and paramedical staff are at high risk of developing Hepatitis B, infection. Hepatitis B vaccine is mandatory for medical students prior to admission in medical colleges. After completion of vaccination determination of anti HBS is not in practice. All over the world some people remain non responders and don't develop adequate antibody titre essential for protection against hepatitis B virus. This study is therefore designed to estimate the anti HBs titre among the medical students, who have completed three doses of hepatitis B vaccine. Objectives: To determine the serum anti HBs antibodies among the outgoing final year MBBS students who have received complete 03 doses of hepatitis B vaccine. Study Design: Descriptive cross sectional study. Place and Duration: This study was conducted from November 2010 to December 2015 at Biochemistry department Punjab Medical College in collaboration with Nawaz Medicare Hospital Faisalabad. Material and Methods: Two hundred and fifty nine female medical (MBBS) students from outgoing classes during the period of November 2010 to December 2015 were enrolled in this study. All subjects were at the age of 22-24 years at the time of sampling. Each received 03 doses of injection Engerix B, 10 mcg/0.5ml each in a schedule of 0, 01, 06 months since the last 05 years. The blood samples were allowed to clot and serum was separated. The anti HBs and HBsAg were determined by 3 rd generation ELISA method. Results: A total 259 female medical students from outgoing final year MBBS classes were enrolled in this study. Among these subjects 48 (18.5%) had serum anti HBs levels < 10 IU/L, 77 subjects (29.7%) have levels 10-20 IU/L, 116 subjects (44.8 %) have serum levels 21-100 IU/L, while 18 subjects (10%) have > 100 IU/L serum anti HBs levels. Conclusion:The incidence of non responders and poor responders is higher among the vaccinees in this study as compared to foreign studies after five years of Hepatitis B vaccination.
Objective: To determine the success rate of goniotomy in terms of reduction in intraocular pressure. Study Design: Quasi-experimental study. Place and Duration of Study: Department of Ophthalmology, at Faisalabad Medical University/Allied Hospital Faisalabad from Apr 2016 to Aug 2017. Methodology: A total of 65 patients were enrolled in our study. The patients with intraocular pressure greater than 21 mm Hg and corneal diameter less than 13 millimetres were included. Intraocular pressure was measured before and four-weeks after goniotomy. Intraocular pressure measurement of less than 21 mm Hg four- weeks after surgery was considered successful. Results: Out of 65 patients, 35 (53.8 %) were male, and 30 (46.2%) were female. The age of patients ranged from 3 months to 33 months, with a mean age of 15.25 ± 7.66 months. Among 65 patients operated for goniotomy, the procedure was found successful in 55 (84.6%) patients, and only 10 (15.4%) patients did not show improvement following goniotomy. The fall in intraocular pressure from baseline to post-operative values of intraocular pressure was statistically significant (p-value < 0.01). Conclusions: Goniotomy is an effective procedure for lowering intraocular pressure in childhood glaucoma patients and can be offered as a primary and initial procedure at an early age.
A100 Background According to available data the lung cancer remains the leading malignancy amongst males showing a strongest association with smoking. The study was conducted to analyze the histological classification of primary lung cancer in relation to age, gender and types of Tobacco Smoking Methods The study was conducted on randomly selected 300 patients of 10-90 years age from Ghulab Devi Chest Hospital Lahore. Light microscopy was used for histopathological classification on the sections stained with haematoxylin and eosin. Special (PAS and Alcian blue) stains were used for subclassication. Literature for WHO classification was reviewed. Results The primary malignancy of lung was more common in males (male to female ratio was 5.7:1) and in old ages with mean age was 54.17±3.46 years.. Significantly large numbers of patients (70%) were smokers. The trend of smoking is changing in Pakistan from old traditional hukka to cigarette. A strong association of smoking was found between small cell carcinoma (SCC), and squamous cell carcinoma (SQCC), and Large cell carcinoma (LCC), (P<0.02, P< 0.001 and p<0.02 respectively). No significant difference was seen between smokers and non smokers harboring adenocarcinoma (ADC;P>0.05). According to the WHO classification, SQCC (43%) was found to be the commonest histological variant and SCC (22%) was second in the frequency. The frequency of ADC, LCC and others variants was 18%, 11%and 5% respectively. Conclusion WHO criteria are the better ways to classify the lung carcinoma with light microscopy and provide a potential widespread and worldwide application of this classification system. A strong association of lung cancer was found with age, sex, and all types of smoking and histological variants. Citation Information: Cancer Prev Res 2008;1(7 Suppl):A100.
Introduction: The doctors and paramedical staff are at high risk of developingHepatitis B, infection. Hepatitis B vaccine is mandatory for medical students prior to admissionin medical colleges. After completion of vaccination determination of anti HBS is not in practice.All over the world some people remain non responders and don’t develop adequate antibodytitre essential for protection against hepatitis B virus. This study is therefore designed to estimatethe anti HBs titre among the medical students, who have completed three doses of hepatitisB vaccine. Objectives: To determine the serum anti HBs antibodies among the outgoing finalyear MBBS students who have received complete 03 doses of hepatitis B vaccine. StudyDesign: Descriptive cross sectional study. Place and Duration: This study was conductedfrom November 2010 to December 2015 at Biochemistry department Punjab Medical College incollaboration with Nawaz Medicare Hospital Faisalabad. Material and Methods: Two hundredand fifty nine female medical (MBBS) students from outgoing classes during the period ofNovember 2010 to December 2015 were enrolled in this study. All subjects were at the ageof 22-24 years at the time of sampling. Each received 03 doses of injection Engerix B, 10mcg/0.5ml each in a schedule of 0, 01, 06 months since the last 05 years. The blood sampleswere allowed to clot and serum was separated. The anti HBs and HBsAg were determined by3rd generation ELISA method. Results: A total 259 female medical students from outgoing finalyear MBBS classes were enrolled in this study. Among these subjects 48 (18.5%) had serumanti HBs levels < 10 IU/L, 77 subjects (29.7%) have levels 10-20 IU/L, 116 subjects (44.8 %)have serum levels 21-100 IU/L, while 18 subjects (10%) have > 100 IU/L serum anti HBs levels.Conclusion: The incidence of non responders and poor responders is higher among thevaccinees in this study as compared to foreign studies after five years of Hepatitis B vaccination.
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