Anti HBS Titre; Among Outgoing Final Year MBBS Students

Abstract

ABSTRACT… Introduction:The doctors and paramedical staff are at high risk of developing Hepatitis B, infection. Hepatitis B vaccine is mandatory for medical students prior to admission in medical colleges. After completion of vaccination determination of anti HBS is not in practice. All over the world some people remain non responders and don't develop adequate antibody titre essential for protection against hepatitis B virus. This study is therefore designed to estimate the anti HBs titre among the medical students, who have completed three doses of hepatitis B vaccine. Objectives: To determine the serum anti HBs antibodies among the outgoing final year MBBS students who have received complete 03 doses of hepatitis B vaccine. Study Design: Descriptive cross sectional study. Place and Duration: This study was conducted from November 2010 to December 2015 at Biochemistry department Punjab Medical College in collaboration with Nawaz Medicare Hospital Faisalabad. Material and Methods: Two hundred and fifty nine female medical (MBBS) students from outgoing classes during the period of November 2010 to December 2015 were enrolled in this study. All subjects were at the age of 22-24 years at the time of sampling. Each received 03 doses of injection Engerix B, 10 mcg/0.5ml each in a schedule of 0, 01, 06 months since the last 05 years. The blood samples were allowed to clot and serum was separated. The anti HBs and HBsAg were determined by 3 rd generation ELISA method. Results: A total 259 female medical students from outgoing final year MBBS classes were enrolled in this study. Among these subjects 48 (18.5%) had serum anti HBs levels < 10 IU/L, 77 subjects (29.7%) have levels 10-20 IU/L, 116 subjects (44.8 %) have serum levels 21-100 IU/L, while 18 subjects (10%) have > 100 IU/L serum anti HBs levels. Conclusion:The incidence of non responders and poor responders is higher among the vaccinees in this study as compared to foreign studies after five years of Hepatitis B vaccination.

Seroprotection of Hepatitis B Vaccine in Dental Students Two Decades after Infant Immunization and the Possible Need for Revaccination

“…13 However, determination of the anti-HBs antibody titer is not in practice after completion of vaccination. 8 The aim of this study was to assess the persistence of anti-HBs antibody after two decades of infant vaccination among dental students and determine the immune response after revaccination of nonimmune participants.…”

“… 13 However, determination of the anti-HBs antibody titer is not in practice after completion of vaccination. 8 …”

“…This confirms the findings of previous studies that the immunity effect of hepatitis B vaccine diminishes with time. 8 17 18 …”

“…[5][6][7] Although the effectiveness of the hepatitis B vaccination is evident, the duration of protection after vaccination is not exactly known in addition to the fact that some people remain nonresponders to vaccine and do not develop adequate anti hepatitis B surface antigen titer (anti-HBs) essential for protection against HBV. 8,9 As determination of anti-HBs response after completion of infant vaccination is not in practice in Saudi Arabia, the aim of this study was to assess the seroprotection of hepatitis B vaccine in dental students at the Umm Al-Qura University two decades after infant immunization and also to deter-mine the immune response after adult revaccination among students with nonprotective antibody level.…”

“…Although the effectiveness of the hepatitis B vaccination is evident, the duration of protection after vaccination is not exactly known in addition to the fact that some people remain nonresponders to vaccine and do not develop adequate anti hepatitis B surface antigen titer (anti-HBs) essential for protection against HBV. 8 9 …”