Abstrak: Senyawa benzalhidantoin atau 5-benzilidena-imidazolidina-2,4-dion (3) merupakan senyawa yang dapat diisolasi dari spons merah laut Laxosubrites sp. dan memiliki aktivitas antikejang serta antikanker prostat PC-3M. Senyawa tersebut sudah disintesis sejak beberapa dekade yang lalu dan banyak diteliti bioaktivitasnya, baik di bidang kesehatan maupun pertanian. Penelitian di bidang kesehatan, contohnya sebagai agen antikonvulsan, antivirus, inhibitor EGFR dan antiproliferasi sel A431, antikanker sel HepG2, antimetastatik sel kanker PC-3M, inhibitor enzim tirosinase dan pembentukan melanin serta di bidang pertanian sebagai herbisida dan fungisida. Tujuan dari penelitian ini adalah mensintesis senyawa 5-(4'-klorobenzilidena)-imidazolidina-2,4-dion (7) melalui reaksi kondensasi antara hidantoin (1) dengan 4-klorobenzaldehida (2) menggunakan pereaksi natrium bikarbonat dalam etanol, dan etanolamina sebagai katalis basa (metode Eli Lily). Hidantoin (1) dan 4-klorobenzaldehida (2) sebagai senyawa prekursor diperoleh secara komersil. Sintesis dilakukan dengan cara mereaksikan senyawa hidantoin (1) dan 4-klorobenzaldehida (2) secara stokiometri dengan katalis basa etanolamina dalam etanol dan air (modifikasi metode Eli Lily) dan direfluks selama 6 jam. Senyawa hasil sintesis dimurnikan dengan cara rekristalisasi dari etanol panas, diperoleh kristal putih berbentuk jarum 5-(4'-klorobenzilidena)-imidazolidina-2,4-dion (7) dengan rendemen 12%. Senyawa tersebut dianalisis dengan menggunakan KLT silika gel GF 254 , aseton-heksana (1:1 v/v) memberikan harga R f = 0,625 untuk senyawa
Vegetables are one of the horticultural commodities that have high economic value and opportunity in the market. However, vegetables supply chain in Indonesia is often identified with the traditional supply chain of long marketing chains, difficult market access for farmers, low competitiveness, farmers’ low income, and injustice to supply chain actors, especially between farmers and wholesalers. In creating a structured supply chain, value co-creation intervention applied to synergize farmers and wholesalers in Ciwidey Sub-district to understand each other’s problems then seek solutions to solve them. This research has been conducted in Ciwidey Sub-district, West Java. This research aims to measure the competitiveness and farmers income of each wholesaler’s group before and after value co-creation intervention. The result shows that variables competitiveness and income of Sari Hejo Farmer Group and Hidayah Alam Farmer Group have significant positive changed, while one of three indicator variable of competitiveness has not significantly changed.
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