This study aims to evaluate the effectiveness of onion peel tea supplementation on body composition, lipid profile, serum glucose concentration, blood glucose level, hypercholesterolemia-related risk factors, cardiovascular disorders in obese, and overweight females. Females attending Diabetic center National Hospital with a Basal metabolic index greater than 25 are randomly selected, assigned to the control group, aerobic training (AT), Onion Peel tea Supplementation (OPT), as well as AT and OPT groups. OPT group received 33 mg of onion peel tea supplementation after every meal a day in addition to AT for 6 months including 90 min of AT sessions that helped get 80% of the target heart rate. One week before the study and 3 days after the last AT session, all participants were subjected to take their blood samples. In comparison to control group weight, total body fat percentage including visceral fat and subcutaneous fat, body mass index (BMI), high-density lipoproteins (HDL), low-density lipoproteins, blood pressure, heart rate, and triglycerides show a significant decrease in AT and AT+OPT groups. No significant changes were obtained in HDL and waist to hip ratio. AT gave beneficial effects in improving Cardiovascular risk factors, hypertension, and LDL.
Postural Orthostatic Tachycardia Syndrome (POTS) is a form of dysautonomia associated with variety of symptoms like Headache, Abdominal discomfort, Dizziness/presyncope, Nausea, Fatigue, Lightheadedness, Sweating Sleep disorder, Tremor, Anxiety, Palpitations, Exercise intolerance which is believed to be caused by an underlying infectious and/or autoimmune trigger. HYQVIA is an immune globulin with a recombinant human hyaluronidase indicated for the treatment of Primary Immunodeficiency (PI) in adults. This includes, but is not limited to, common variable immunodeficiency (CVID), X-linked agammaglobulinemia, congenital agammaglobulinemia, Wiskott-Aldrich syndrome, and severe combined immunodeficiencies. HYQVIA is a gammaglobulin and is a slow metabolizer given subcutaneously once a month.There is data that Intravenous immunoglobulin(IVIg) helps POTS patients. We present a case of 57 year old female diagnosed with autonomic failure,orthostatic intolerance and primary immune deficiency. She was given IVIg for primary immune deficiency. She was previously reported for severe autonomic failure. From then, she was doing extremely well, had more energy and she thinks more clearly. She also had much better attitude. She was getting albumin every 2 weeks or so for volume expansion. She felt IVIg had helped her. Her immunoglobulin was switched from Gammagard to HYQVIA 35 grams. After she did, her blood pressure had gone up. She took it with albumin and she felt palpitations and chest pain.She was stopped on albumin, as albumin and HYQVIA combined could cause more volume expansion and push her into fluid overload or even congestive heart failure. After she stopped albumin without HYQVIA, she did well. Similarly, she cut back on midodrine which is an α1 adrenergic agonist, and works by stimulating receptors that noradrenaline normally works on. After swallowing, midodrine is rapidly converted into another, more active drug that binds to noradrenaline receptors causing blood vessels to narrow, thereby increasing blood pressure andreduction in heart rate in POTS patients. She was only HYQVIA and had been feeling extremely well.
Background: Postural Orthostatic Tachycardia Syndrome (POTS) is a form of dysautonomia that is estimated to impact between 1,000,000 and 3,000,000 Americans and millions more around the world. Patients chronically have symptoms that are worse with upright posture and that improve with recumbence. Symptoms often include orthostatic intolerance such as dizziness, fatigue, excessive sweating and many others. The aim of this study is to determine the variation of symptoms early morning after wake up and evening at 4 PM. Methods: The Autonomic nervous system questionnaire consisting of eight POTS symptoms palpitations, headaches, dizziness, shortness of breath(SOB), chest pain, weakness, blurred vision and heaviness of feet was handover to the patients at our clinic. 42 POTS patients participated in the study, participated patients had been asked to scale their symptoms early morning after wake up and evening at 4 PM. Symptoms were defined 0 as Never,1 as mild,2 as moderate,3 as severe ,4 as extreme and 5 impairing daily function and living. Results: Out of 42 POTS patients 90% are female (38/42, age 31.74±10.67) and 10% are males (4/42, age 30.75±13.20), symptoms were scaled early morning after wake up vs symptoms scaled evening at 4 pm results in mean±SD and Anova P value. Palpitations 1.69±1.32 vs 2.45±1.38 (P =0.01), Dizziness 2.40±1.38 vs 2.67±1.46 (P =0.40), Chest pain 0.93±1.02 vs 1.52±1.27 (P=0.02), SOB 1.36±1.32 vs 1.81±1.40 (P=0.13), Weakness 2.79±1.37 vs 3.12±1.38 (P=0.27), Blurred vision 1.38±1.29 vs 1.48±1.27 (P=0.73), Headaches 1.74±1.36 vs 2.52±1.38 (P =0.01), Heaviness of feet 0.95±1.19 vs 1.43±1.53 (P =0.11). Conclusion: Our study results demonstrated that the patients with POTS had significant variation in symptoms Palpitations, Chest pain, Headaches in evenings when compared to early morning after wake up.
Background: Postural Orthostatic Tachycardia Syndrome (POTS) is a form of dysautonomia that is estimated to impact between 1,000,000 and 3,000,000 Americans and millions more around the world. Symptoms often include orthostatic intolerance such as dizziness, fatigue, excessive sweating and many others. The aim of this study is to determine the Q-sweat study in POTS patients. Methods: This study was a randomized, single-blind study. Patients evaluated between October 2014 to June 2015 were included. The skin on the leg and wrist is wiped with acetone, then alcohol and dried, cleaning the skin in preparation for the test. Four electrodes filled with acetylcholine are placed on three areas of the leg and one area on the wrist. A mild electrical current called iontophoresis is then applied to help the drug stimulate the sweat glands. This evokes sweating at the site, but it also allows the body to release its own acetylcholine, resulting in sweat production at nearby sites. After a stimulus (e.g. a deep breath) any deviation from the baseline is reported. If no change is seen, a stronger stimulus is applied (e.g. electrical stimulation) and if there is still no change seen, an “absent response” is reported. The onset latency and magnitude of response can be quantified, although the results are highly variable within and between subjects. The sweat response is measured Q-sweat recordings of Left proximal leg, Left distal leg and Left foot sites were analyzed. Results are categorized as Normal response, no response, hung up and prolong response. Results: A total 144 POTS patients were included, Out of 144 POTS patients 88% are females (n=127, mean age 31.93±12.37) and 12% are males (n=17, mean age 31.59±11.14), Left proximal leg site 69/144(48%) Patients had hung up, 8/144(6%) had No response, 29/144(20%) had Normal, 38/144(26%) had Prolong. Left distal leg site 72/144(50%) had hung up, 13/144(9%) had No response, 23/144(16%) had Normal, 36/144(25%) had Prolong. Left foot site 36/144(25%) had hung up, 35/144(24%) had No response, 40/144(28%) had Normal, 33/144(23%) had Prolong response. Conclusion: Postural Orthostatic Tachycardia Syndrome had a higher percentage of patients with Hung up response.
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