No abstract

Recently, obesity has been recognized as a global health and economic problem due to rising health care cost for sufferers. 3 Current conventional health care for obese people still uses synthetic drugs that are known to have many side effects and reduce quality of life. 5 Therefore, many studies have been conducted to prevent and reduce diabetes. One of the studies was conducted by utilizing the bioactive and pharmacogenic potential of natural ingredients in herbal medicines as anti-obesity. P. oleracea is a cosmopolitan succulent species of the Porthulaceae family that is distributed in tropical and subtropical areas. 6 This plant is reported as one of the herbal medicines that has been widely used in treating degenerative diseases such as liver disease, obesity, and dyslipidemia. [7][8][9] Several studies showed that this plant was able to reduce glucose levels in mice on days 7 and 14 (dose of 125, 250, 500 mg/ kg) (P < 0.05). 10 Based on the potential effects of P. oleracea and the many scientific publications regarding the potential of purslane to treat obesity and overweight, the purpose of this review article is to discuss and conclude the potential of P. oleracea in treating obesity, overweight and other diseases associated with the metabolic syndrome.

This research aimed to determine the topical administration effect of the combination of Sargassum duplicatum and Garcinia mangostana extracts to ameliorate diabetic open wound healing. The study used 24 adult males of Mus musculus (BALB/c strain, 3–4 months, 30–40 g). They were divided into normal control groups (KN) and diabetic groups. The diabetic group was streptozotocin-induced and divided further into three treatment groups: the diabetic control group (KD), the S. duplicatum treatment group (PA), and the combination of S. duplicatum and G. mangostana treatment group (PAM). The dose of treatment was 50 mg/kg of body weight. Each group was divided into three treatment durations, which were 3 days, 7 days, and 14 days. The wound healing process was determined by wound width, the number of neutrophils, macrophages, fibroblasts, fibrocytes, and collagen density. Histological observation showed that the topical administration of combination extracts increased the re-epithelialization of the wounded area, fibroblasts, fibrocytes, and collagen synthesis. The topical administration of combination extracts also decreased the number of neutrophils and macrophages. This study concluded that the topical administration of the combination of S. duplicatum and G. mangostana extracts improved the open wound healing process in diabetic mice.