The study describes the current state of knowledge on nanotechnology and its utilization in medicine. The focus in this manuscript was on the properties, usage safety, and potentially valuable applications of chitosan-based nanomaterials. Chitosan nanoparticles have high importance in nanomedicine, biomedical engineering, discovery and development of new drugs. The manuscript reviewed the new studies regarding the use of chitosan-based nanoparticles for creating new release systems with improved bioavailability, increased specificity and sensitivity, and reduced pharmacological toxicity of drugs. Nowadays, effective cancer treatment is a global problem, and recent advances in nanomedicine are of great importance. Special attention was put on the application of chitosan nanoparticles in developing new system for anticancer drug delivery. Pre-clinical and clinical studies support the use of chitosan-based nanoparticles in nanomedicine. This manuscript overviews the last progresses regarding the utilization, stability, and bioavailability of drug nanoencapsulation with chitosan and their safety.
Self-healing polymers, which can spontaneously recover themselves after being ruptured, result in enhanced lifetimes for materials and open up a fascinating direction in material science. Macrocycle-based host-guest interactions, one of the most crucial non-covalent interactions, play a key role in self-healing material fabrication. This review aims to highlight the very recent and important progress made in the area of self-healing polymer materials by focusing on cyclodextrins (CDs), crown ethers, cucurbit[n]urils (CBs), calix[n]arenes and pillar[n]arenes with special guest groups and tailored structures. In addition, we also propose future research directions and hope that this review can in a way reflect the current situation and future trends in this developing area.
Nanoparticle dispersion is important
for the performance of rubber
compounds. Herein, ionic liquids (ILs) and silane are used to prepare
silica-filled butadiene rubber vulcanizates. The results show that
replacement of a half of silane by ILs could greatly improve the dispersions
of silica and zinc oxide, restrain the migration of sulfur and other
additives inside the composite, and maintain the cross-linking degree
of the matrix possibly by suppressing the adsorption of sulfur and
other additives by silica. The regulated filler dispersity and matrix
cross-linking strongly influence the dynamic rheological behaviors
of the vulcanizates as a function of silica volume fraction. In comparison
with silane, the introduction of ILs could improve the reinforcement
effect, reduce energy dissipation, and lower the frequency dependences
of loss modulus and loss tangent in the linear region.
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