We do not find any correlation between tumor stage or site and MUC1, MUC2 or MUC5AC expression. MUC1and MUC5AC expression showed significant correlation with tumor grade.
Giant soft tissue chondromas (STCs) of the wrist are seldom encountered in clinical practice. Precise diagnosis of benign STC may pose diagnostic difficulties on clinical and radiological findings alone. We encountered a slowly growing soft tissue neoplasm in the radial aspect of the wrist joint of the right hand in a 52-year-old male, masquerading as a calcified hematoma, as suggested by magnetic resonance imaging. On cytohistopathological examination, it turned out to be a rare giant STC. The variable cellularity, in conjunction with cellular immaturity and atypia, could mislead one to a malignant pathological interpretation. Diagnosis is based on both radiological and cytohistological evaluation, which is indispensable for determining the tumor type. The detailed clinical, radiological, cytomorphological, and immune-histopathological study was carried out, which has prompted us to report this case along with a review of the literature.
Multilocular Cystic Renal Neoplasm of Low Malignant Potential (MCRNLMP) represents a rare variant of clear cell (conventional) renal carcinoma. They constitute between 3-6% of clear cell Renal Cell Carcinoma (RCC). The RCC constitutes less than 1% of all renal tumours. The MCRNLMP has an excellent prognosis with no reports of recurrence or metastasis. Authors reported a case of 67-year-old male patient on account of its rarity, co-existing pyelonephritis and incidental detection of MCRNLMP. Differentiation between MCRNLMP, RCC variants and other cystic lesions with clear cells is important as prognosis, treatment differ markedly. Radiological Bosnaik classification of complex cysts in category IIF and III is challenging and requires microscopic examination for correct diagnosis. Histopathology shows cysts separated and fibrous septae having groups of clear cells with low grade nuclei. Immunohistochemistry with Carbonic Anhydrase-IX (CA-IX), Epithelial Membrane Antigen (EMA), Cytokeratin (CK7) and CD10 is confirmatory. Diagnosis requires detailed imaging studies, meticulous grossing of nephrectomy specimens, extensive sampling of cystic tissue to find clear cells and immunohistochemistry (IHC).
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