We describe the SemEval task of extracting keyphrases and relations between them from scientific documents, which is crucial for understanding which publications describe which processes, tasks and materials. Although this was a new task, we had a total of 26 submissions across 3 evaluation scenarios. We expect the task and the findings reported in this paper to be relevant for researchers working on understanding scientific content, as well as the broader knowledge base population and information extraction communities.
publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
EditorialDigital healthcare: The only solution for better healthcare during COVID-19 pandemic?
Keywords:Digital healthcare COVID-19 pandemic a b s t r a c tThe huge impact of the COVID-19 pandemic on global healthcare systems has prompted search for novel tools to stem the tide. Attention has turned to the digital health community to provide possible health solutions in this time of unprecedented medical crisis to mitigate the impact of this pandemic. The paper shall focus on how digital solutions can impact healthcare during this pandemic.
We consider the problem of recommending comment-worthy articles such as news and blog-posts. An article is defined to be comment-worthy for a particular user if that user is interested to leave a comment on it. We note that recommending commentworthy articles calls for elicitation of commenting-interests of the user from the content of both the articles and the past comments made by users. We thus propose to develop content-driven user profiles to elicit these latent interests of users in commenting and use them to recommend articles for future commenting. The difficulty of modeling comment content and the varied nature of users' commenting interests make the problem technically challenging.The problem of recommending comment-worthy articles is resolved by leveraging article and comment content through topic modeling and the co-commenting pattern of users through collaborative filtering, combined within a novel hierarchical Bayesian modeling approach. Our solution, Collaborative Correspondence Topic Models (CCTM), generates user profiles which are leveraged to provide a personalized ranking of comment-worthy articles for each user. Through these content-driven user profiles, CCTM effectively handle the ubiquitous problem of cold-start without relying on additional meta-data. The inference problem for the model is intractable with no off-the-shelf solution and we develop an efficient Monte Carlo EM algorithm. CCTM is evaluated on three real world data-sets, crawled from two blogs, ArsTechnica (AT) Gadgets (102,087 comments) and AT-Science (71,640 comments), and a news site, DailyMail (33,500 comments). We show average improvement of 14% (warm-start) and 18% (cold-start) in AUC, and 80% (warm-start) and 250% (cold-start) in Hit-Rank@5, over state of the art [1, 2].
Tumor cells promote immune evasion through up regulation of PD-L1 that binds with PD1 on cytotoxic T cells and promote dysfunction. Though therapeutic efficacy of anti PD1 antibody has remarkable effects on different type of cancers it is less effective in breast cancer. Hence more details understanding of PD-L1 mediated immune evasion is necessary. Here we report breast cancer cells secrete extra cellular vesicles in form of exosomes carry PD-L1 and is highly immunosuppressive. TGF-β present in tumor micro-environment orchestrates breast cancer cell secreted exosomal PD-L1 load. Circulating exosomal PD-L1 content is highly correlated with tumor TGF-β level. The later also found to be significantly associated with CD8+CD39+, CD8+PD1+ T cell phenotype. Recombinant TGF-β1 dose dependently induces PD-L1 expression in Texos in vitro and blocking of TGF-β dimmed exosomal PD-L1 level. PD-L1 knocked down exosomes failed to suppress effector activity of activated CD8 T cells like tumor exosomes. While understanding its effect on TCR signalling we found siPD-L1 exosomes failed to block phosphorylation of src family proteins, LAT and PLCγ of CD8 T cells more than PD-L1 exosomes. In-vivo inhibition of exosome release and TGF-β synergistically attenuates tumor burden by promoting Granzyme and IFN-γ release in tumor tissue depicting rejuvenation of exhausted T cells. Thus we establish TGF-β as a promoter of exosomal PD-L1 and unveil a mechanism that tumor cells follow to promote CD8 T cell dysfunction.
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