Our data failed to show the non-inferiority of 1 mg of GRN to 3 mg of GRN administered as a single dose. However, the rate of complete protection from nausea and vomiting was similar in the two groups. Given the recommended dosage in the guidelines and the economic need for reduction of medical care expenses in Japan, prophylactic administration of GRN at 1 mg may be an appropriate, alternative treatment for acute CINV in cancer patients.
Axially symmetric half-wave plates have been used to generate radially polarized beams that have constant phase in the plane transverse to propagation. However, since the retardance introduced by these waveplates depends on the wavelength, it is difficult to generate radially polarized beams achromatically. This paper describes a technique suitable for the generation of achromatic, radially polarized beams with uniform phase. The generation system contains, among other optical components, an achromatic, axially symmetric quarter-wave plate based on total internal reflection. For an incident beam with a constant phase distribution, the system generates a beam with an extra geometrical phase term. To generate a beam with the correct phase distribution, it is therefore necessary to have an incident optical vortex with an azimuthally varying phase distribution of the form exp( + iθ). We show theoretically that the phase component of radially polarized beam is canceled out by the phase component of the incident optical vortex, resulting in a radially polarized beam with uniform phase. Additionally, we present an experimental setup able to generate the achromatic, uniform-phase, radially polarized beam and experimental results that confirm that the generated beam has the correct phase distribution.
Vectorial vortex analysis is used to determine the polarization states of an arbitrarily polarized terahertz (0.1–1.6 THz) beam using THz achromatic axially symmetric wave (TAS) plates, which have a phase retardance of Δ = 163° and are made of polytetrafluorethylene. Polarized THz beams are converted into THz vectorial vortex beams with no spatial or wavelength dispersion, and the unknown polarization states of the incident THz beams are reconstructed. The polarization determination is also demonstrated at frequencies of 0.16 and 0.36 THz. The results obtained by solving the inverse source problem agree with the values used in the experiments. This vectorial vortex analysis enables a determination of the polarization states of the incident THz beam from the THz image. The polarization states of the beams are estimated after they pass through the TAS plates. The results validate this new approach to polarization detection for intense THz sources. It could find application in such cutting edge areas of physics as nonlinear THz photonics and plasmon excitation, because TAS plates not only instantaneously elucidate the polarization of an enclosed THz beam but can also passively control THz vectorial vortex beams.
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