On March 29, 1989, an abnormal calf birth occurred in Okayama Prefecture. The abnormal calf displayed the inability to stand and extended any of its four limbs.
Over a 2-year period from January, 1984 to December, 1985, there were 46 bovine cases of abnormal births. Of these cases, 10 were abortion, 11 stillbirths, and 25 abnormal newborn calves with kyphosis, blindness, infirmity, hydrocephalia and cerebellar hypoplasia. All the calves had cerebellar encephalitis. Seven stillborn young had neutralizing antibody to Ibaraki virus, but not antibodies to Akabane virus or bovine viral diarrhea-mucosal disease virus. It was suggest that these cases of abnormal births might have been caused by infection with Ibaraki virus or a virus which had the same antigen as this virus.
It is known that the localized form of herpes simplex virus (HSV) infection does not always show a good prognosis. A preterm infant who evidenced skin and tongue lesions, caused by HSV type 1, was treated by acycloguanosine. The result was satisfactory without any complications. Therefore, a localized form of HSV infection of the newborn infant, even though the patient has a low-birth-weight, should be treated by the drug immediately after the observation of the positive HSV culture.
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