An Abnormal Calf Birth Suggestive of an Infection of Ainovirus in Okayama Prefecture

Fukutomi, Toyoko; Ouchi, Motoaki; Okuda, Kouken; Maruno, Fumio; Tabayashi, K

doi:10.12935/jvma1951.44.17

Cited by 7 publications

(5 citation statements)

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“…The high incidence of these teratologic lesions in AIV-inoculated chick embryos confirmed our previous data (under submission) producing lesions very similar to those found in spontaneous cases of congenital abnormalities of the calves suspected of being infected with API (1,3,4,7,10). The fact that the present higher virus titer was recovered from the CNS and skeletal muscles of the chick embryos preceded the appearance of deformities proved that proliferation of AIV in the host cells of these organs were the primary cause of the abnormalities.…”

Section: Mentsupporting

confidence: 88%

“…Anti-AIV antibody have been detected in the sera of horses, cows, pigs and humans (5), although pathological changes resulting from AIV-infection have not been known. However, AIV has been suspected to be a causative agent of congenital abnormalities of calves in Japan (3,4,7,10) and Australia (1), whose principal gross lesions were hydranencephaly and arthrogryposis, frequently accompanied with cerebellar hypoplasia. Experimental AIV-infection of pregnant ewes at 90 days of gestation could not testify infection to and pathogenicity against the fetuses (24).…”

mentioning

confidence: 99%

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Proliferation and Teratogenicity of Aino Virus in Chick Embryos

Kitano

Ohzono

Shimizu

1996

Microbiology and Immunology

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Aino virus (AIV; JaNAr 28 strain) 103 TCID50/0.2 ml was inoculated in the yolk sac of 8-day-old chick embryos. Recovery and titration of the virus from various organs including the central nervous system (CNS) and skeletal muscle were performed at 2, 4, 7, 10 and 13 days after inoculation (PI). AIV was systemically disseminated and proliferated even 2 days PI. The titers of the recovered virus from the CNS and from skeletal muscle was the highest at 4 days PI and declined with time, whereas hydranencephaly, arthrogryposis and cerebellar hypoplasia developed at 7 days PI and gradually progressed until 13 days PI.

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Section: Mentsupporting

confidence: 88%

mentioning

confidence: 99%

Proliferation and Teratogenicity of Aino Virus in Chick Embryos

Kitano

Ohzono

Shimizu

1996

Microbiology and Immunology

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“…AKAV infections have been reported in Australia [ 14 ], Japan [ 15 , 33 , 37 ], the Middle East [ 31 ], South Korea [ 18 , 23 ], and Taiwan [ 19 ]. AINOV infections have also been reported in Japan [ 6 , 40 ]. Vaccines have also been developed.…”

mentioning

confidence: 99%

Seroprevalence of bovine arboviruses belonging to genus <i>Orthobunyavirus</i> in South Korea

Jun

Yanaka

Lee

et al. 2018

The Journal of Veterinary Medical Science

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Arboviruses, belonging to the Simbu serogroup of the genus Orthobunyavirus, often cause congenital malformations and reproductive loss in cattle. The recent occurrences of such reproductive problems suggest that new arboviruses have emerged in Japan. However, there is no information on the presence of these viruses in South Korea. The aim of this study was to determine the presence of antibodies for Akabane, Aino, Peaton, Sathuperi, and Shamonda viruses in four regions, namely Gyeonggi, Jeollabuk, Jeollanam provinces, and Jeju Island of South Korea by a serum neutralization test. Antibody positivity against Akabane, Aino, Peaton, Sathuperi, and Shamonda viruses was detected in the country, with average seropositive rates of 10.4, 4.5, 1.1, 4.9, and 5.6%, respectively.

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“…During the outbreak of bovine congenital abnormalities caused by AKAV in Japan in 1972-1975, the precolostral sera of several affected calves with A-H syndrome contained antibodies to AINOV, but not to AKAV (53). Since then, cases suspected of being associated with AINOV have been sporadically reported in the western part of Japan (99)(100)(101)(102). AINOV was also obtained from an aborted bovine fetus with brain lesions (103,104).…”

Section: Aino Virus Infectionmentioning

confidence: 99%

Endemic and Emerging Arboviruses in Domestic Ruminants in East Asia

2020

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Epizootic congenital abnormalities caused by Akabane, Aino, and Chuzan viruses have damaged the reproduction of domestic ruminants in East Asia for many years. In the past, large outbreaks of febrile illness related to bovine ephemeral fever and Ibaraki viruses severely affected the cattle industry in that region. In recent years, vaccines against these viruses have reduced the occurrence of diseases, although the viruses are still circulating and have occasionally caused sporadic and small-scaled epidemics. Over a long-term monitoring period, many arboviruses other than the above-mentioned viruses have been isolated from cattle and Culicoides biting midges in Japan. Several novel arboviruses that may infect ruminants (e.g., mosquito-and tick-borne arboviruses) were recently reported in mainland China based on extensive surveillance. It is noteworthy that some are suspected of being associated with cattle diseases. Malformed calves exposed to an intrauterine infection with orthobunyaviruses (e.g., Peaton and Shamonda viruses) have been observed. Epizootic hemorrhagic disease virus serotype 6 caused a sudden outbreak of hemorrhagic disease in cattle in Japan. Unfortunately, the pathogenicity of many other viruses in ruminants has been uncertain, although these viruses potentially affect livestock production. As global transportation grows, the risk of an accidental incursion of arboviruses is likely to increase in previously non-endemic areas. Global warming will also certainly affect the distribution and active period of vectors, and thus the range of virus spreads will expand to higher-latitude regions. To prevent anticipated damages to the livestock industry, the monitoring system for arboviral circulation and incursion should be strengthened; moreover, the sharing of information and preventive strategies will be essential in East Asia.

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An Abnormal Calf Birth Suggestive of an Infection of Ainovirus in Okayama Prefecture

Abstract: On March 29, 1989, an abnormal calf birth occurred in Okayama Prefecture. The abnormal calf displayed the inability to stand and extended any of its four limbs.

Cited by 7 publications

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Proliferation and Teratogenicity of Aino Virus in Chick Embryos

Proliferation and Teratogenicity of Aino Virus in Chick Embryos

Seroprevalence of bovine arboviruses belonging to genus <i>Orthobunyavirus</i> in South Korea

Endemic and Emerging Arboviruses in Domestic Ruminants in East Asia

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