This study examined the effect of the Dietary Approaches to Stop Hypertension (DASH) diet containing lean red meat on measures of body composition and muscle strength in a cohort of obese adults 65 and older; 36 males (n = 15) and females (n = 21) consumed 1800 kcal/day for 12 weeks under controlled feeding conditions. The study diet included daily intakes of 126 g of meat. Measures of body composition and muscle strength were obtained at weeks 0, 3, 6, 9, and 12. Breakfast, lunch, and dinner were provided every day for 12 weeks, and equal portions of meat were distributed at each meal. Significant effects of the study diet were detected across time for total body weight, body mass index (BMI), waist circumference, hip circumference, body fat percentage, absolute fat mass (AFM), and blood pressure such that a decrease (p < 0.001) was observed over 12 weeks. Significant effects of the study diet were detected across time for sit/stand (p < 0.001) such that an increase was observed. From baseline to study end, total body weight decreased by 6.3% (p < 0.001), body fat percentage decreased by 2.5% (p < 0.001), and absolute fat mass (AFM) decreased by 4.4 kg (p < 0.001). By the study end, skeletal muscle mass (SMM) was positively correlated with handgrip strength (R2 = 0.75; p = 0.001) and resting energy expenditure (REE) (R2 = 0.29; p = 0.001). Handgrip strength, gait, balance, and resting energy expenditure (REE) were well maintained (p > 0.05) throughout the study. These findings suggest that the DASH diet has the potential to be a tool to preserve muscle strength while reducing fat mass in obese older adults.

Objective: To examine the response of a calorie-restricted Dietary Approaches to Stop Hypertension diet on indicators of cardiometabolic health in a cohort of sedentary obese older adults.Design: This was a controlled-feeding trial with a parallel design. Each participant consumed either 3 oz (85 g; n = 15) or 6 oz (170.1 g; n = 13) of lean fresh beef within a standardized calorie-restricted DASH-like diet for 12-weeks. Fasted blood samples were collected and used to measure conventional biomarkers of cardiovascular, metabolic and inflammatory health.Participants: Caucasian older (70.8 years), obese (BMI: 32 ± 6.9 kg/m2; WC: 101 ± 16.4 cm) females (n = 17) and males (n = 11) from the rural community of Brookings, South Dakota.Results: 28 participants completed the 12-week feeding trial, with no differences (p &gt; 0.05) among the biomarkers of cardiometabolic health between the 3 and 6 oz beef intake groups. However, when the beef intake groups were combined, all biomarkers changed concentration in response to the intervention diet. Total cholesterol (p &lt; 0.001), LDL-C (p = 0.004), HDL-C (p &lt; 0.0001), insulin (p = 0.014), glucose (p = 0.008), HOMA-IR (p &lt; 0.05), IL-12 (p &lt; 0.001), and CRP (p = 0.006) all decreased in response to the study diet. IGF-1 (p &lt; 0.001) and IL-8 (p = 0.005) increased in response to the intervention. Correlations among cardiometabolic biomarkers and body composition measures were observed. By study end, the decrease in insulin (R2 = 0.22; P = 0.012) and HOMA-IR (R2 = 0.22; P = 0.01) was positively correlated with the decrease in waist circumference. The increase in IGF-1 was significantly correlated with the decrease in waist circumference (R2 = 0.21; p = 0.014). The increase in IGF-1 was significantly correlated with the increase in sit-to-stand (R2 = 0.21; p = 0.016). The increase in IL-8 was significantly correlated with decreases in total cholesterol (R2 = 0.24; P = 0.008), LDL-C (R2 = 0.17; P = 0.031) and glucose (R2 = 0.44; P = 0.0001).Conclusions: These findings suggest that a DASH-like diet with restricted calories may potentially improve biomarkers of cardiometabolic health in sedentary obese older adults. These results also point to interrelationships between body composition changes and changes in cardiometabolic biomarkers. Lastly, regardless of meat intake amount, positive impacts on cardiometabolic biomarkers were observed in this cohort of older adults with an obese phenotype.

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<p class="abstract"><strong>Background:</strong> Knee osteoarthritis is a notable issue in senior citizens and is a burning problem worldwide. There are so many risk factors related to knee osteoarthritis but women's sex, age, and obesity are significant. The aim and objective of this study were to estimate the prevalence of knee osteoarthritis among women in the age group of 46 to 65 years and the effect of age and body mass index (BMI) on knee osteoarthritis.</p><p class="abstract"><strong>Methods:</strong> Cross-sectional study was conducted at outpatient department (OPD) in Mymensingh Medical College Hospital, a tertiary level hospital, among females of Mymensingh, a divisional city of Bangladesh in the age group of 46 to 65 years. Purposive sampling technique used to select study subjects. A total of 100 females participated in this study in one month (July 2019-August 2019).<strong></strong></p><p class="abstract"><strong>Results:</strong> 100 participants were enlisted in the study, in the age group of 46 to 55 years 39 (39%) and 56 to 65 years 61 (61%). Total 65 (65%) participants were affected with knee osteoarthritis. Among them, 19 (29.2%) participants were in the age group of 46-55 years and 46 (70.8%) participants were in the age group of 55-65 years, thus in the advanced age group, knee osteoarthritis is remarkably more. Participants affected with knee osteoarthritis with BMI ≥25 were significantly more affected 45 (69.2%) compared with participants with normal BMI 20 (30.2%).</p><p class="abstract"><strong>Conclusions:</strong> Knee osteoarthritis is significantly associated with advanced age and obesity. Advanced age and overweight were strongly associated with osteoarthritis in our population. Therefore, weight reduction and preventive measures can decrease the burden and will help in minimizing morbidity associated with OA.</p>