2021
DOI: 10.3389/fnut.2021.647847
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Abstract: Objective: To examine the response of a calorie-restricted Dietary Approaches to Stop Hypertension diet on indicators of cardiometabolic health in a cohort of sedentary obese older adults.Design: This was a controlled-feeding trial with a parallel design. Each participant consumed either 3 oz (85 g; n = 15) or 6 oz (170.1 g; n = 13) of lean fresh beef within a standardized calorie-restricted DASH-like diet for 12-weeks. Fasted blood samples were collected and used to measure conventional biomarkers of cardiova… Show more

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Cited by 9 publications
(18 citation statements)
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“…Dora et al found that this CR regimen reduced oxidative stress in male and female adults, as indicated by the urinary concentration of F2-isoprostane ( 29 ). Another study indicated that 12 weeks of CR improved cardiometabolic health in sedentary adults with obesity and aged ≥65 years ( 14 ). Age-related loss of skeletal muscle quantity and quality is associated with reduced gait speed and overall strength and a high risk of fall and frailty.…”
Section: Cr and Frailtymentioning
confidence: 99%
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“…Dora et al found that this CR regimen reduced oxidative stress in male and female adults, as indicated by the urinary concentration of F2-isoprostane ( 29 ). Another study indicated that 12 weeks of CR improved cardiometabolic health in sedentary adults with obesity and aged ≥65 years ( 14 ). Age-related loss of skeletal muscle quantity and quality is associated with reduced gait speed and overall strength and a high risk of fall and frailty.…”
Section: Cr and Frailtymentioning
confidence: 99%
“…Caloric restriction (CR) is defined as a reduction in energy intake (typically by 20-40% of ad libitum consumption) without malnutrition (11). CR has been reported to considerably extend a healthy lifespan and prevent age-related diseases in both animals and humans (11)(12)(13)(14). However, the previous studies have mainly focused on the association between CR and aging, and few studies have explored the relationship between CR and frailty.…”
Section: Introductionmentioning
confidence: 99%
“…The impact of diet on changes in myostatin concentrations and parallel changes in muscle and metabolic health in humans remains unexplored. In a controlled-feeding dietary intervention study in which adults aged 65 years and older consumed a calorie-restricted Dietary Approaches to Stop Hypertension (DASH) diet for 12-weeks, we observed improved changes in body composition and biomarkers of cardiometabolic health characterized by decreases in waist circumference and fat mass, muscle strength maintenance with an increase in strength-to-weight ratio, reduced cholesterol and improved insulin sensitivity [ 18 , 19 ]. Extending the scope of these findings and given the role that myostatin plays in muscle and metabolic health, we sought the following: (i) to evaluate the changes in circulating myostatin levels in response to a calorie-restricted DASH diet in older adults; (ii) to assess associations between myostatin, body composition and cardiometabolic biomarkers in this cohort of older adults; and (iii) considering the role that follistatin plays as an antagonist of myostatin, we assessed the changes in follistatin concentrations in response to the diet intervention.…”
Section: Introductionmentioning
confidence: 99%
“…Subject characteristics, recruitment, and study diet have been previously reported [ 18 , 19 ]. Briefly, older sedentary adults ( > 65-years) were recruited from Brookings, South Dakota between June 2017 to August 2018.…”
Section: Introductionmentioning
confidence: 99%
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