Aluminium is present in some manufactured medicines and foods. It is known that aluminium causes oxidative stress. Therefore, the present study was undertaken to determine the effectiveness of Haloxylon salicornicum extract in modulating aluminium chloride (AlCl 3) induced oxidative stress in rats. Male rats (40 to 50 g) were divided into four groups of six animals each. The experimental protocol was based on the administration of AlCl 3 (30 mg/kg/body weight) intraperitoneally (ip) every 5 days for 15 days. The groups treated with the plant receive daily dose of 0.05 g/kg/body weight. Increased level of aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), urea, and creatinine in serum indicated hepatic and renal dysfunction. The variation of catalase (CAT), superoxide dismutase (SOD), reduced glutathione (GSH), and lipid peroxidation (thiobarbituric acid reactive substances, TBARS) were assessed. These parameters indicated the extent of oxidative damage in liver and kidney, thus confirming the histology results in liver and kidney. It was found that the consumption of H. salicornicum extract protects the liver and kidney against aluminium chloride toxicity. The aim of the present study was to evaluate the protective effect of the H. salicornicum extract on the damages caused by administration of aluminium chloride (AlCl 3) in young rats.
Aluminium is present in many manufactured foods and medicines and is also used in water purification. It is known that aluminium causes oxidative stress. Therefore, the present study was undertaken to determine the effectiveness of vitamin E (VE) in modulating the toxicity of aluminium chloride (AlCl3) on biochemical parameters, antioxidant enzymes and lipid peroxidation in serum and different organs (liver and kidney) of male Wistar rats. 24 rats (150-180g) were divided into four groups of six animals each : control ; Al was administered intraperitoneally (50 mg/kg/bw, one times a week) ; VE was given orally at a daily dose (100 mg/kg/bw) and Al+VE group. The experiment during for 90 days. AlCl3 caused a decreased in body weight consumption along with increased in the absolute and relative liver and kidney weights. TBARS level was increased, and the enzymes activities of CAT and SOD were decreased in liver and kidney of rats treated with AlCl3. While, TBARS was decreased and the antioxidant enzymes were increased in rats treated with VE. The hepatic and renal damage induced by Al was evidenced by a increase in the levels of serum AST, ALT, LDH, ALP, γGT, glucose, urea, creatinine and bilirubin, while total protein and albumin were decreased due to AlCl3 administration. These parameters indicated the extent of oxidative damage in liver and kidney, thus confirming the histology results in these organs. It can be concluded in this study that presence of VE effectively atte-nuated AlCl3 induced hepatotoxicity and nephrotoxicity in rats. It has benefi-cial influences and protective effect against AlCl3 toxicity.
Lead is a persistent and common environmental contaminant that can be found in food and water. It is well-known that lead acetate causes hyperten-sion, disturbance of lipid metabolism in humans and animals. Nowadays, the phytotherapy remains a very interesting field to recovery of deleterious effect of heavy metals. The aim of this study was to evaluate the effects of aqueous extract of Artemisia absinthium to modulating the effect of lead acetate induced changes in systolic and diastolic blood pressure levels, lipid profiles in serum, heart, aorta and liver tissues and determination of lead burden in blood, when added to intoxicated animal. Male rats (80-120) g were divided into four groups of six animals each. Intoxicated animals re-ceived intraperitoneally (i.p) injections of lead acetate (20 mg/kg/body weight) solution for 4 weeks every two days. Rats treated with plant receive orally the extract of A.absinthium (5%) for 4 weeks. Orally administration of the wormwood extract in rats intoxicated with lead acetate decreased sig-nificantly the systolic (SBP), diastolic blood pressure (DBP) and blood lead level. Levels of total lipids, TC and TG were decreased significantly in group (Pb+PL) compared to control, especially in heart and liver tissues. In serum, a significant elevation of TC and TG was noted in intoxicated rats compared to control. The cardiac damage induced by Pb was evidenced by an increase in the levels of LDH and AST. In conclusion, the data indicate that the worm-wood extract has a significant ability to reduce hypertension, blood lead lev-el, equilibrate lipid metabolism and cardiac enzymes level.
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