Protective effect of Haloxylon salicornicum on hepatic and renal functions of Wistar rats exposed to aluminium

Abstract

Aluminium is present in some manufactured medicines and foods. It is known that aluminium causes oxidative stress. Therefore, the present study was undertaken to determine the effectiveness of Haloxylon salicornicum extract in modulating aluminium chloride (AlCl 3) induced oxidative stress in rats. Male rats (40 to 50 g) were divided into four groups of six animals each. The experimental protocol was based on the administration of AlCl 3 (30 mg/kg/body weight) intraperitoneally (ip) every 5 days for 15 days. The groups treated with the plant receive daily dose of 0.05 g/kg/body weight. Increased level of aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), urea, and creatinine in serum indicated hepatic and renal dysfunction. The variation of catalase (CAT), superoxide dismutase (SOD), reduced glutathione (GSH), and lipid peroxidation (thiobarbituric acid reactive substances, TBARS) were assessed. These parameters indicated the extent of oxidative damage in liver and kidney, thus confirming the histology results in liver and kidney. It was found that the consumption of H. salicornicum extract protects the liver and kidney against aluminium chloride toxicity. The aim of the present study was to evaluate the protective effect of the H. salicornicum extract on the damages caused by administration of aluminium chloride (AlCl 3) in young rats.

Effects of thymoquinone against D- galactose and aluminum chloride induced testicular dysfunction in rats.

“…Recent animal and clinical studies have reported that Al causes neuropathological changes in the central nervous system [5]. Al can accumulate in the liver and kidneys, causing hepatorenal toxicity [6]. Al also has prooxidative, excitotoxic, immunogenic, proinflammatory, and mutagenic effects [7].…”

Hesperidin protects against aluminum-induced renal injury in rats via modulating MMP-9 and apoptosis: biochemical, histological, and ultrastructural study

“…Moreover, aluminum pots represent around 20% of the relative multitude of pots on the planet. Aluminum is additionally present in water suitable for human use with a convergence of 0.2 mg/L, water-filtering specialists, jars and containers, foil paper made from aluminum, and beauty care products (Fatima et al 2016 ). Thusly, human beings are highly susceptible to aluminum toxicity as it may accumulate in the kidney causing nephrotoxicity due to its high availability (Fatima et al 2016 ).…”

“…Aluminum is additionally present in water suitable for human use with a convergence of 0.2 mg/L, water-filtering specialists, jars and containers, foil paper made from aluminum, and beauty care products (Fatima et al 2016 ). Thusly, human beings are highly susceptible to aluminum toxicity as it may accumulate in the kidney causing nephrotoxicity due to its high availability (Fatima et al 2016 ). Additionally, aluminum can liberate receptive oxygen species (ROS) and apoptosis by animating the favorable to oxidant effects of iron and copper, resulting in mitochondrial dysfunction and subsequent oxidative deterioration of macromolecules and releasing of cytochrome C from the mitochondria (Al-Olayan et al 2015 ; Zahedi-Amiri et al 2019 ).…”

Effects of Acute Aluminium Exposure on Liver Cytoarchitecture of Adolescent Female Wistar Rats

“…[10,11] The generated ROS, in turn, can lead to lipid peroxidation perturbing the membranous integrity, oxidative damage of protein and nucleic acid. [12,13] Various tissues are reported to be the target of Al-induced effects. The induced oxidative stress by Al ultimately causes harmful effect on liver, [14] kidney, heart, reproductive organs and nervous system causing degenerative impacts.…”