Female Long-Evans rats, were given a purified PGA-deficient diet containing 10mg% of the antimetabolite, g-methyl-PGA, from days 8 to 10 of gestation, followed by a PGA-supplemented diet from day 10 to autopsy. This regimen resulted in 18% embryonic death by day 11, 65% by day 12, and 100% by day 13 of pregnancy.No morphological differences between PGA-deficient and control embryos were observed at nine or nine and one-half days but ten-day embryos showed retardation of
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