ObjectiveThis systematic review aimed to present the available literature on plasma cell vulvitis (PCV), a relatively uncommon form of inflammatory vulvovaginal dermatitis.Materials and MethodsA literature search was performed in PubMed, Science Direct, and Google Scholar using the following key words: “plasma cell vulvitis,” “Zoon vulvitis,” and “vulvitis circumscripta plasmacellularis.” Specific variables were assessed in each article, including patient age, menopausal status, comorbidities, presenting symptoms, symptom duration, histological description, treatment, and treatment response.ResultsThirty-nine articles met inclusion criteria, including 38 case reports and 1 observational study, with a total of 96 cases of PCV reported. The mean age of diagnosis was 52.9 years, with an age range of 8–76 years. Most common presenting symptoms included pruritis and vaginal discomfort, with average duration of symptoms 28.2 months (range = 2 months to 10 years). All reports demonstrated subepithelial plasma cell infiltrate on histology. Five percent of PCV cases reported concomitant autoimmune conditions and 6% sexually transmitted infections. Most common treatment modalities included topical corticosteroids (n = 41), tacrolimus (n = 6), and imiquimod (n = 6). In 53 reported outcomes, 88.7% of patients had resolution of symptoms with treatment.ConclusionsClinical research is needed to better determine the diagnostic criteria and to assess the efficacy of treatment options for PCV.
Tuberculosis is a serious infection that can appear in many forms and presentations. Here, we highlight a case of a 13 year old patient with a three-month history of nonspecific abdominal pain whose symptoms persisted after treating Typhoid and H. pylori infections. She had subsequent computed- tomography imaging notable for nodular thickening of the omentum and ascites concerning for possible carcinomatosis. Diagnostic laparoscopy with peritoneal biopsy revealed abdominal tuberculosis, and she had resolution of symptoms following appropriate medical therapy. We discuss the risk factors, clinical features, and work-up in the diagnosis of peritoneal tuberculosis.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.