Synthesis of a new hybrid nanocomposite materials, zinc-aluminium-fenoprofen, ZAF was successfully accomplished by self-assembly method with molar ratio of Zn to Al; R=2 at concentration of fenoprofen=0.3 M. As a result of the successful intercalation, the interlayer spacing expanded from 9.8 Å in the zinc-aluminium-layered double hydroxide, ZAL to 20.1 Å in the ZAF hybrid nanocomposite. The FTIR spectra of the ZAF show resemblance peaks of ZAL and fenoprofen indicating the inclusion of the organic compound into the LDH interlamellae. The percentage loading of the guest anion, fenoprofen in ZAL was estimated to be about 63.4% (w/w) calculated from the carbon content.
A nonsteroidal drug, flufenamic acid (FA) was successfully intercalated into magnesium-aluminium-layered double hydroxide, MAL for the formation of magnesium-aluminium-flufenamate-layered double hydroxide, MAF by self-assembly technique. As a result of the successful intercalation, basal spacing increased from 9.8 Å in the MAL to 23.5 Å in the MAF hybrid nanocomposite. The FTIR spectra of the MAF hybrid nanocomposite show resemblance peaks of the MAL and FA suggesting the inclusion of the organic compound into the MAL interlamellae. The percentage loading of FA was found to be 74.4 % (w/w) calculated from the percentage of carbon in the resulting material, MAF.
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