Sex differences in the clinical presentation of substance-dependent individuals with psychiatric comorbidity present specific treatment challenges and opportunities.

Pathologic gamblers experienced stronger cravings than did ADS. This may be a disturbing experience for PG and a potential cause for relapse. The higher scores on novelty seeking concur with previous studies that associate PG and impulsivity. ADS higher scores on harm avoidance suggest anxiety vulnerability. The positive relation between alcohol craving, anxiety, and harm avoidance suggests that ADS rely on alcohol to deal with a proclivity to negative emotions. The positive relation of gambling craving to depression and negative relation to reward dependence suggests that individuals who have a lesser susceptibility to experience positive emotions are the ones who most miss gambling when abstaining.

Introduction: Obsessive-compulsive disorder (OCD) is a heterogeneous condition, in which subtypes have been proposed. Previous studies suggested that gender plays a relevant role in OCD phenotypic expression. This study aimed to review the literature on gender differences in clinical, genetic or familial aspects of OCD. Method: A conventional review was conducted, including all papers that investigated demographic, clinical, and genetic aspects of OCD according to gender. The search was based on data available in Medline and PsycINFO databases in the last 20 years, using as keywords: obsessive-compulsive disorder; and: gender, sex, male, female, demographic characteristics, clinical features, clinical characteristics, genetic, genes, genetics gender OCD, genes OCD, genes OCD males, genes OCD females. Results: Sixty three of 487 phenotypical and genetics studies were selected. Most studies indicate that male patients are more likely than females to be single, present early onset of symptoms and chronic course of the disorder, greater social impairment, more sexual-religious and aggressive symptoms, and greater comorbidity with tic and substance use disorders. Female patients present more contamination/cleaning symptoms and greater comorbidity with eating and impulse-control disorders. Genetic and family studies are inconclusive, but suggest that gender may play a role in the disease expression. Conclusions: Gender is a relevant factor that should be taken into account when evaluating OCD patients. More studies are necessary to determine whether in fact it defines a homogeneous and particular group in OCD. ©2011 Elsevier Editora Ltda. All rights reserved. Gender differences in obsessive- DesCRIPToRs:Obsessive-compulsive disorder; Gender identity; Sex; Phenotype; Genetics. ReVIeW ARTICLe 391Gender differences in obsessive-compulsive disorder: a literature review Diferenças de gênero no transtorno obsessivo-compulsivo: uma revisão da literatura ResumoIntrodução: O transtorno obsessivo-compulsivo (TOC) é um quadro heterogêneo, no qual subtipos têm sido propostos. Estudos anteriores sugerem que gênero desempenha papel relevante na expressão fenotípica. O objetivo foi realizar uma revisão convencional da literatura sobre diferenças de gênero em relação a aspectos clínicos e genéticos ou familiares do TOC. Método: Realizou-se uma revisão convencional da literatura incluindo todos os artigos que investigaram aspectos sociodemográficos, clínicos e genéticos do TOC, de acordo com o gênero. A pesquisa foi baseada em publicações disponíveis nas bases de dados Medline e PsycInfo nos últimos 20 anos, usando como palavras-chave: obsessive-compulsive disorder (OCD), e: gender, sex, male, female, demographic characteristics, clinical features, clinical characteristics, genetic, genes, genetics gender OCD, genes OCD, genes OCD males, genes OCD females. Resultado: Sessenta e três artigos de fenótipo e genética foram selecionados. Na maioria dos estudos, o sexo masculino associou-se mais que o feminino com: ser solteiro, ap...

Background: Individual differences may impact susceptibility to addiction. The impact of personality features on drug craving, however, has not been studied, particularly in women.

Alcohol and drug use among university students: gender differences Uso de álcool e drogas entre estudantes universitários: diferença entre os gêneros Concerning the consumption reported in the last 12 months, both genders displayed significant increases in the consumption of marijuana (22.3% to 27.1% for men and 12.9% to 16.9% for women), amphetamines (1.9% to 5.0% for men and 3.4% to 5.6% for women), and inhalants (9.8% to 15.7% for men and 5.4% to 10.6% for women). The greatest gender difference was observed in consumption reported in the last 30 days with significant increases in male use of tobacco (19.6% to 23.5%), marijuana (15.8% to 20.5%), amphetamines (1.1% to 3.2%), and inhalants (4.0% to 7.9%). Substance use reported in the last 30 days remained stable among women between the 2 surveys. Conclusion: Rates of substance use among university students increased. These gender differences in substance consumption should be taken into account in the development of preventive and treatment strategies for undergraduate university students. Entre os homens, observou-se aumento significativo no uso durante a vida de tabaco (de 44,8% para 50,9%), maconha (de 33,7% para 39,5%) e alucinógenos (de 6,6% para 14,1%) entre os anos de 1996 e 2001. Não foi observada diferença significativa entre as mulheres no uso de tranquilizantes ao longo da vida entre 1996 e 2001. Para o consumo relatado nos últimos 12 meses, para ambos os gêneros observou-se aumento significativo no uso de maconha (de 22,3% para 27,1% entre os homens e de 12,9% para 16,9% entre as mulheres), anfetaminas (de 1,9% para 5,0% entre os homens e de 3,4% para 5,6% entre as mulheres) e inalantes (de 9,8% para 15,7% entre os homens e de 5,4% para 10,6% entre as mulheres). A maior diferença entre os gêneros foi observada no consumo relatado nos últimos 30 dias, com aumento significativo no consumo de tabaco entre os homens (de 19,6% para 23,5%), maconha (de 15,8% para 20,5%), anfetaminas (de 1,1% para 3,2%) e inalantes (de 4,0% para 7,9%). O uso de substâncias relatado nos últimos 30 dias permaneceu estável para as mulheres entre os dois levantamentos. Conclusão: Observou-se aumento no uso de diversas substâncias entre os estudantes universitários. As diferenças observadas entre os gêneros quanto ao uso de substâncias devem ser levadas em conta quando do desenvolvimento de estratégias preventivas e de tratamento para essa população.

Objective:The authors evaluated the association of three functional promoter polymorphisms of the ADH4 gene with alcohol dependence.Method: DNA from 92 alcohol-dependent patients and 92 healthy comparison subjects was genotyped for all three polymorphisms.Results: Variants at the -75 base-pair (bp) (C allele) and -159 bp (A allele) positions were associated with alcohol dependence. Individuals with haplotypes carrying both risk alleles showed an odds ratio of 2.9. Conclusions:These preliminary results suggest that ADH4 may play a role in the etiology of alcohol dependence. The association requires further study and replication but is functionally plausible and has a large effect size. (Am J Psychiatry 2005; 162:1005-1007)

The authors compared 39 women and 38 men entering an outpatient treatment program for pathological gambling. They were diagnosed according to DSM-IV and selected by SOGS, followed by a semi-structured interview for demography and progression of the gambling behavior prior to treatment. Women were more often single (59% vs. 26%; p = .005) and started gambling significantly later than men (34.2 vs. 20.4 years; p < .001). The progression of the disorder was more than 2 times faster in women than in men. There was no difference in the age of seeking treatment (44.7 vs. 42.3 years). Findings from this study resemble gender differences in other addictions--in particular the faster progression among women--challenge pharmacodynamic hypotheses for this phenomenon, and suggest gender into account when devising treatment strategies for pathological gambling.

ResumoContexto: A felicidade é uma emoção básica caracterizada por um estado emocional positivo, com sentimentos de bem-estar e de prazer, associados à percepção de sucesso e à compreensão coerente e lúcida do mundo. Nos últimos anos, diversos pesquisadores têm se preocupado em desvendar as relações entre felicidade e saúde mental. Objetivo: Revisar criticamente a literatura científica que aborda o tema da felicidade, assim como as suas contribuições para a saúde mental e a psiquiatria. Métodos: Revisão sistemática da literatura por meio do indexador MedLine, utilizando-se dos unitermos: happiness, mental health, well-being, positive psychology, resilience, optimism, gratitude, quality of life, positive emotions, personality. Resultados: Variáveis como origem, saúdes física e mental, religiosidade e determinadas características psicológicas se associam positivamente à felicidade. Não há evidências de que idade, gênero, estado civil, poder aquisitivo nem ocorrência de eventos externos (favoráveis ou não) se associem significativamente à felicidade. Conclusão: A felicidade é um fenômeno predominantemente subjetivo, estando subordinada mais a traços psicológicos e socioculturais do que a fatores externamente determinados. A identificação desses fatores é particularmente útil na subpopulação que é mais predisposta a doenças mentais, favorecendo o desenvolvimento de abordagens preventivas, com potencial repercussão nas áreas social e ocupacional.Ferraz, R.B. et al. / Rev. Psiq. Clín 34(5); 234-242, 2007 Palavras-chave: Felicidade, bem-estar, emoções positivas, saúde mental, psiquiatria. AbstractBackground: Happiness is a basic emotion characterized by a positive emotional state, with feelings of well-being and pleasure, associated with a perception of sucess and a coherent and lucid comprehension of the world. Recently, several researchers have been involved in the elucidation of the relationship between happiness and mental health. Objective: Critically review the scientific literature concerning the topic happiness and its contributions to mental health and to psychiatry. Methods: Systematic review of the literature through the MedLine database, using the uniterms: happiness, mental health, well-being, positive psychology, resilience, optimism, gratitude, quality of life, positive emotions and personality. Results: Variables such as origin, physical and mental health, religiosity and certain psychological characteristics are positively associated with happiness. There is no evidence suggesting that age, gender, marital status, wealthiness or the occurrence of external factors (favorable or not) significantly associate with happiness. Conclusion: Happiness is a predominantly subjective phenomenon, subordinated to psychological and socio-cultural traits much more than to external factors. The identification of these factors is particularly useful when applied to subjects that are more predisposed to mental disorders, favoring the development of prevention approaches, which have potential repercussion in the social...