1 The contribution of endogenous endothelins to nociceptive responses elicited by ovalbumin (OVA) in the hind-paw of mice sensitised to this antigen (50 mg OVA þ 5 mg Al(OH) 3 , s.c., 14 days beforehand) was investigated. 1 mg). Treatment with BQ-123 (3 nmol, i.pl.) reduced only the hyperalgesic effect of compound 48/80, whereas BQ-788 (3 nmol) was ineffective. 6 Thus, immune-mediated Type I hypersensitivity reactions elicit mast cell-and endothelindependent nociception in the mouse hind-paw, which are mediated locally by both ET A and ET B receptors. The nocifensive response to antigen is amenable to blockade by systemic treatment with dual ET A /ET B or selective ET A receptor antagonists, but is sharply potentiated by systemic selective ET B receptor antagonist treatment. The apparently distinct roles played by ET B receptors in this phenomenon at local and other sites remain to be characterised.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.