It appears that the direct absorption spectroscopy of hemolysate samples, therefore, may be utilized as a supplementary technique for the estimation of HbA1c (%), even at the primary healthcare centers.

Summary Background Preeclampsia, a rapidly progressing pregnancy-specific multi-systemic syndrome is globally the leading cause of maternal and neonatal morbidity and mortality. This study aims to evaluate the serum total Lactate dehydrogenase levels in women with preeclampsia when compared to normotensive pregnant women and assess the electrophoretic pattern of the LDH isoenzymes in normal pregnancy, preeclampsia and eclampsia. Methods The study, carried out in the Department of Biochemistry of MVJ Medical College, included 30 patients of preeclampsia and 30 normotensive gestational age-matched pregnant women admitted to the Department of OBG. Serum total LDH was analysed by DGKC method. Serum and cord blood samples for isoenzyme distribution analysis were collected from a normal pregnant woman undergoing delivery, a woman with mild eclampsia, two women with eclampsia, and analysed by slab gel electrophoresis followed by activity staining. Results LDH was significantly elevated in cases as well as between the case (mild and severe) groups, showed a moderate positive statistically significant correlation with systolic, diastolic blood pressure and a sensitivity of 50% and a specificity of 80%. Further, the isoenzyme pattern showed a decreasing distribution of aerobic forms of LDH in preeclampsia-eclampsia. Conclusions Preeklampsija, multisistemski sindrom koji brzo napreduje zbog trudnoće, vodeći je uzrok morbiditeta i mortaliteta majki i novoro|enčadi. Ova studija ima za cilj da proceni nivo ukupne laktat dehidrogenaze u serumu kod žena sa preeklampsijom u poređenju sa normotenzivnim trudnicama i proceni elektroforetski obrazac LDH izoenzima u normalnoj trudnoći, preeklampsiji i eklampsiji.

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Introduction and Aim: Various biochemical and hematological variables are important for predicting the progression of diabetes to diabetic complications, analyzing health-economic status, and examining the effectiveness of antidiabetic agents. The aim of this study is to find the association between clinical variables and type 2 diabetes, diabetic nephropathy and cardiovascular disease.   Materials and Methods: A total of 300 participants’ details were studied and divided into 3 groups; type 2 diabetes (n=100), diabetic nephropathy (n=100), and cardiovascular disease (n=100). Various biochemical and hematological variable data were collected from the patient file. BUN and inflammatory markers such as NLR, PLR, LMR and SII were calculated. P value (0.05) is statistically significant.   Result: A comparison of biochemical data, such as HbA1c, urea, creatinine, and sodium, revealed statistically significant differences between the three groups. Hematological parameters, such as RBC, Hb, WBC, PCT, and RDW, were also found to be significant. We calculated BUN, BCR, NLR, PLR, LMR, and SII and found they were significant.   Conclusions Clinical variables along with HbA1c as one of the most significant predictors can help define a person's risk profile for type 2 diabetes and the progression of diabetic complications. It may offer a new challenge to health education and therapeutic interventions designed to prevent diabetic complications.