Our study emphasized the implementation of preventive measures like education and needle exchange program as harm-reduction strategies. Drop in Centers are important for the management of health problems, including HIV infection and social problems such as crime. Periodic epidemiological studies on DICs are necessary to monitor and modulate the services delivered by these centers.
Objectives:To compare the effect of exercise and morphine on abstinence syndrome and hippocampal gene expression in rat model.Methods:Thirty adult male rats were exposed to voluntary wheel exercise (low, medium, high) for 28 days. The subjects entered Conditioned Place Preference (CPP) apparatus and experienced morphine (low, medium, high) CPP and followed by naloxone test. Correlation between exercise level, morphine injection, concurrent morphine administration and exercise with morphine CPP, BDNF and TrkB genes was determined. Rats were euthanized, decapitated and the hippocampus was removed. The expression of BDNF and TrkB genes were evaluated by real time PCR.Results:Active rats ran an average of 839.18 m/d. A significant (P<0.001) correlation between exercise level, morphine injection, concurrent morphine administration and exercise with morphine CPP and BDNFand TrKB gene expressions was found.Conclusion:Voluntary exercise in different levels potentiates the brain rewarding system, CPP scale, and hippocampal BDNF and TrKB expressions. High range of voluntary exercise demonstrated an increase in the likelihood of developing addictive and drug-seeking behavior.
Background:Reversal learning has proven to be a valuable task in assessing the inhibitory process that is central to executive control. Psycho-stimulants and music are prevalent factors that influence cognition.Objectives:The present study aimed at investigating the influences of dexamphetamine and music on inhibitory control.Materials and Methods:This experimental study was conducted between May and June 2014 in the laboratory animal center of Shiraz University of Medical Sciences, Shiraz, Iran. Thirty mice were divided to five groups including a control group, a witness group, and three experimental groups. Food availability was restricted in order to maintain the subjects at 85% of their free-feeding body weight for behavioral testing. After discrimination learning, animals received four injections of 2 mg/kg dexamphetamine at two-hour intervals. The music group was exposed to music half an hour before reversal learning.Results:According to the results of the repeated measure analysis of variance (ANOVA), music increased errors (mean difference: -2.40, 95% CI: -3.59 to -1.22), yet dexamphetamine had no significant effect on reversal learning. Due to various advantages, we transited to the mixed model that showed increasing (Beta: 2.2 95% CI: 0.26 to 4.13) and borderline (Beta: 1.8 95% CI: -0.13 to 3.73) effects on the number of errors for dexamphetamine and music group, respectively.Conclusions:Drug-treated subjects were impaired in their ability to modulate behavior, based upon changing information about stimulus-reward associations, possibly due to the inability to inhibit their response. These effects may have relevance to some mental disorders such as drug-abuse, schizophrenia, and obsessive-compulsive disorder.
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