Effect of exercise and morphine on psychological and physical dependencies, BDNF and TrkB gene expression in rat’s hippocampus

Naghshvarian, Mojtaba; Zarrindast, Mohammad‐Reza; Mehr, Shahram Ejtemaei; Ommati, Mohammad Mehdi; Sajjadi, Seyedeh Fatemeh

doi:10.12669/pjms.333.12342

Cited by 10 publications

(10 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Structural changes in the developing human brain following acute and chronic morphine exposure may also be due to alterations in neuronal differentiation and neurite outgrowth genes like NTRK2 [36]. Indeed, NTRK2 levels have been shown to increase in the hippocampus of morphine-dependent rats [37]. With the involvement of GNAS in the activation of GPCRs like the opioid receptors, it has been suggested that GNAS may mediate the effects of morphine in the development of tolerance and dependence [38].…”

Section: Discussionmentioning

confidence: 99%

Integrated Systems Analysis of Mixed Neuroglial Cultures Proteome Post Oxycodone Exposure

Guda

Odegaard

Tan

et al. 2021

IJMS

View full text Add to dashboard Cite

Opioid abuse has become a major public health crisis that affects millions of individuals across the globe. This widespread abuse of prescription opioids and dramatic increase in the availability of illicit opioids have created what is known as the opioid epidemic. Pregnant women are a particularly vulnerable group since they are prescribed for opioids such as morphine, buprenorphine, and methadone, all of which have been shown to cross the placenta and potentially impact the developing fetus. Limited information exists regarding the effect of oxycodone (oxy) on synaptic alterations. To fill this knowledge gap, we employed an integrated system approach to identify proteomic signatures and pathways impacted on mixed neuroglial cultures treated with oxy for 24 h. Differentially expressed proteins were mapped onto global canonical pathways using ingenuity pathway analysis (IPA), identifying enriched pathways associated with ephrin signaling, semaphorin signaling, synaptic long-term depression, endocannabinoid signaling, and opioid signaling. Further analysis by ClueGO identified that the dominant category of differentially expressed protein functions was associated with GDP binding. Since opioid receptors are G-protein coupled receptors (GPCRs), these data indicate that oxy exposure perturbs key pathways associated with synaptic function.

show abstract

Section: Discussionmentioning

confidence: 99%

Integrated Systems Analysis of Mixed Neuroglial Cultures Proteome Post Oxycodone Exposure

Guda

Odegaard

Tan

et al. 2021

IJMS

View full text Add to dashboard Cite

show abstract

“…This indicates that the GM is connected to the CNS through BDNF. Morphine use has been shown to increase the expression of BDNF and NTRK2 in the brain ( Numan et al, 1998 ; Akbarian et al, 2002 ; Bolanos and Nestler, 2004 ; Vargas-Perez et al, 2009 ; Koo et al, 2012 ; Mashayekhi et al, 2012 ; Peregud et al, 2016 ; Naghshvarian et al, 2017 ). In our study, the mRNA expression of bndf and ntrk2 in zebrafish increased significantly after morphine administration, while isorhynchophylline reversed this change.…”

Section: Discussionmentioning

confidence: 99%

The Ameliorative Effects of Isorhynchophylline on Morphine Dependence Are Mediated Through the Microbiota-Gut-Brain Axis

et al. 2021

View full text Add to dashboard Cite

Morphine abuse is a global public health problem. Increasing evidence has shown that gut microbiota dysbiosis plays an important role in several central nervous system diseases. However, whether there is an association between gut microbiota and morphine dependence remains unclear. In this study, the effects of isorhynchophylline on morphine dependence were evaluated based on the microbiota-gut-brain axis (MGBA). The results showed that isorhynchophylline could reverse the changes in alpha and beta diversity, composition, and richness of the intestinal flora occurring in morphine-dependent zebrafish, as well as the morphine-induced changes in the expression of MGBA-related genes in BV2 cells and the brain and intestine of zebrafish. Based on the results, we then used antibiotics to evaluate whether disrupting the gut microbiota would affect morphine addiction in zebrafish. The results showed that the antibiotic-induced intestinal floral imbalance changed the behavior of morphine-dependent zebrafish, the characteristics of the zebrafish intestinal flora, and the expression of MGBA-related genes in the zebrafish brain and intestine. Importantly, we also show that, following antibiotic administration, the ameliorative effects of isorhynchophylline on morphine addiction were lost. Together, our results indicate that the gut microbiota interacts with the brain, and dysbiosis of the intestinal flora may affect the efficacy of isorhynchophylline in the body. Our findings provide a novel framework for understanding the mechanisms of morphine addiction through the MGBA and may provide new therapeutic strategies for the use of Chinese medicines in the prevention of drug addiction.

show abstract

“…For example, Naghshvarian et al. (2017) reported that high‐intensity voluntary exercise on a running wheel increases morphine CPP association, showing a positive correlation between the morphine‐paired chamber and the amount of exercise (Naghshvarian et al., 2017). Nevertheless, most clinical and preclinical studies to date do suggest that both voluntary and involuntary exercise attenuate opioid‐seeking behaviors.…”

Section: Effects Of Exercise On Substance Use Disordersmentioning

confidence: 99%

“…Clinical and preclinical studies have shown that drugs of abuse, such as cocaine, methamphetamines, opioids, alcohol, and nicotine, alter BDNF levels (Figure 1), and that this correlates with the development of drug addiction (Chen et al., 2014; Corominas‐Roso et al., 2013; Geoffroy & Noble, 2017; Jamal et al., 2014; Kim et al., 2005; Li & Wolf, 2015; McFadden et al., 2014; Ren et al., 2016; Zanardini et al., 2011; Zhang et al., 2014; Zschucke et al., 2012). In addition, several studies have shown that exercise reduces drug‐seeking behavior by modulation of BDNF signaling (Figure 1) (Miladi‐Gorji et al., 2011; Naghshvarian et al., 2017; Park et al., 2019; Smith & Lynch, 2012; Solomon, 2019). Here, we summarize the literature on these two subjects, aiming to better understand the mechanisms that reduce drug‐seeking behaviors.…”

Section: Effects Of Exercise On Changes Induced By Drugs Of Abuse In ...mentioning

confidence: 99%

See 1 more Smart Citation

Aerobic exercise as a promising nonpharmacological therapy for the treatment of substance use disorders

Marrero-Cristobal

Gelpi-Dominguez

Morales-Silva

et al. 2021

J of Neuroscience Research

View full text Add to dashboard Cite

Substance use disorder (SUD) is a complex condition that involves the induction of molecular and physiological alterations by the use and abuse of illicit substances. The prevalence of illicit drug use has caused this disorder to grow exponentially over the past 5 years (National Institute of Drug Abuse, 2020). To date, there are several FDA-approved pharmacological treatments for substances that may cause dependency, such as heroin, morphine, alcohol, and nicotine, directed to the attenuation of drug craving, and increase time to relapse. Known as medication-assisted treatment, such FDA-approved pharmaceutical interventions can be used to increase the effectiveness of other substance abuse treatments, including the use of buprenorphine (commonly used in opioid use disorder, OUD).Buprenorphine works as a partial agonist that binds to the opioid receptors in the brain, allowing a partial activation of the receptor when it is activated with opioids, and thus reducing the rewarding effects (James & Williams, 2020). Another FDA-approved treatment for OUD is naloxone, a known opioid receptor antagonist that reduces activation and prevents other endogenous ligands to bind to that receptor (Becker & Chartoff, 2019;James & Williams, 2020). These types of pharmacological treatments are still not available for substances such as cocaine, methamphetamines, or cannabis which limit treatment options. The percentage cocaine users aged

show abstract

Effect of exercise and morphine on psychological and physical dependencies, BDNF and TrkB gene expression in rat’s hippocampus

Cited by 10 publications

References 28 publications

Integrated Systems Analysis of Mixed Neuroglial Cultures Proteome Post Oxycodone Exposure

Integrated Systems Analysis of Mixed Neuroglial Cultures Proteome Post Oxycodone Exposure

The Ameliorative Effects of Isorhynchophylline on Morphine Dependence Are Mediated Through the Microbiota-Gut-Brain Axis

Aerobic exercise as a promising nonpharmacological therapy for the treatment of substance use disorders

Contact Info

Product

Resources

About