Bacterial cellulose produced by Gluconacetobacter xylinus is an advantage bacterial product cause of its unique properties, could be used as an ideal dress. The aim of this study was to consider the capability of this biomaterial in release of doxycycline. Proving of this capability provided the outline for production of a dressing containing antibiotic. In this study, bacterial cellulose was synthesized by G.xylinus and loaded from doxycycline then release process was considered in dilute water and buffer phosphate saline. UV-visible spectrophotometry method was applied to measuring the concentration of released drug. Bacterial cellulose structure of chemical was confirmed by Fourier Transform Infrared spectroscopy. Release of doxycycline in dilute water and phosphate saline buffer reach to 73.25% and 94.9%, respectively. Because of more released in buffer solution, peer that process of releasing exhibit exactly results. Results of this study provided the ground for future research on supplying an ideal dressing from this microbial product.
Biopolymer-based hydrogels are commonly used in clinical applications. In the present study, N- succinyl chitosan (NSC), oxidized pectin (OP), and graphene oxide (GO) were used to develop a new dual-crosslinked hydrogel system. The dynamic OP/NSC/GO hydrogel showed quick gelation and great injectability due to the cooperation of hydrogen interaction between the GO nanosheets and the NSC and OP macromolecules and Schiff-based crosslinking by amino and aldehyde functional groups of polysaccharide derivatives. The performance of the above-mentioned hydrogel was improved when the GOs were embedded. When the GO content was 6 (mg/ml), the hydrogel showed the best overall performance, with a 10-minute healing time, a quick gelation time (~ 13s), acceptable swelling ability, suitable conductivity, great hemocompatibility, and strong biological compatibility. These results showed that the composite hydrogel could be used as a promising conductive injectable self-healing hydrogel for tissue engineering applications.
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