Background: This study aimed to investigate the effects of 8-week aerobic training (AT) and saffron supplementation on inflammation and metabolism in middle-aged obese women with type 2 diabetes mellitus (T2DM). Methods: Thirty-two obese women with T2DM were randomly divided into four groups (n = 8 in all groups): saffron + training (ST), placebo + training (PT), saffron supplementation (SS), and placebo (P). The ST and PT groups performed eight weeks of aerobic training (AT) (three sessions/week at 60–75% HRmax). A daily dose of 400 mg saffron powder was consumed by the ST and SS groups for 8 weeks. Blood samples were taken after 12 h of fasting, 48 h before the first AT session, 48 h and two weeks after the last AT session. Results: AT, saffron supplementation, and their combination affected body mass index (BMI), homeostatic model assessment for insulin resistance (HOMA-IR), and serum levels of insulin, adiponectin, interleukin-6 (IL-6), high-density lipoprotein cholesterol (HDL-C), cholesterol, and triglyceride (TG) (p < 0.05). However, body weight, body fat percentage, and serum levels of glucose, resistin, tumor necrosis factor-alpha (TNF-α), irisin, and low-density lipoprotein cholesterol (LDL-C) showed significant changes in the ST group only (p < 0.05). In addition, a significant difference was seen between all factors in post-training and follow-up in the ST group (p < 0.05). Conclusions: Saffron supplementation at a dose of 400 mg/day, when combined with AT, could improve inflammation, metabolism, glycemic status, and lipid profile in T2DM patients, and these changes are sustainable at up to 2 weeks of detraining.
Exercise can ameliorate cardiovascular dysfunctions in the diabetes condition, but its precise molecular mechanisms have not been entirely understood. The aim of the present study was to determine the impact of endurance training on expression of angiogenesis-related genes in cardiac tissue of diabetic rats. Thirty adults male Wistar rats were randomly divided into three groups (N = 10) including diabetic training (DT), sedentary diabetes (SD), and sedentary healthy (SH), in which diabetes was induced by a single dose of streptozotocin (50 mg/kg). Endurance training (ET) with moderate-intensity was performed on a motorized treadmill for six weeks. Training duration and treadmill speed were increased during five weeks, but they were kept constant at the final week, and slope was zero at all stages. Real-time polymerase chain reaction (RT-PCR) analysis was used to measure the expression of myocyte enhancer factor-2C (MEF2C), histone deacetylase-4 (HDAC4) and Calmodulin-dependent protein kinase II (CaMKII) in cardiac tissues of the rats. Our results demonstrated that six weeks of ET increased gene expression of MEF2C significantly (p < 0.05), and caused a significant reduction in HDAC4 and CaMKII gene expression in the DT rats compared to the SD rats (p < 0.05). We concluded that moderate-intensity ET could play a critical role in ameliorating cardiovascular dysfunction in a diabetes condition by regulating the expression of some angiogenesis-related genes in cardiac tissues.
Background: There is a great deal of variability in the response of cortisol and testosterone to different methods of exercise training. One of the methods of exercise that is considered today is the exercises with blood flow restriction. Therefore, this study aimed to compare the changes in hormonal levels of testosterone and cortisol following resistance training with and without blood flow restriction in female athletes.Methods: 30 active females aged 23-30 years were randomly divided into three groups: traditional resistance training, resistance training with blood flow restriction and control. Training started with one set of 30 reps and ended with two sets repeated until exhaustion. Blood sampling prior to and immediately after exercise training took place to measure levels of testosterone and cortisol. T-test for comparison within group and one-way ANOVA was used to compare between groups comparison.Results: Results showed no significant increase for testosterone levels in within and between groups comparison. (P=0/724). Also, cortisol levels were significantly increased only in group without blood flow restriction compared to the pre-test (P=0/001). But in between groups comparison, there was a significant increase in serum levels of cortisol in two training groups compared to the control group (P=0/002). Conclusion:It seems that athletes who are in the rehabilitation phase and are not capable of lifting heavy weights, low intensity exercises with blood flow restriction can be replaced with without blood flow restriction exercises with high intensity.
Background: The increasing prevalence of overweight and related diseases has gained more scientific attention. Overweight and obesity are known as a threat to health, and low serum 25-hydroxy vitamin D levels is associated with obesity. Objectives: Therefore, we examined the effect of Pilates training on body composition, lipid profile, and serum 25-hydroxy vitamin D levels in inactive overweight women. Methods: In this clinical study, 28 overweight women were randomly divided into a training group (n = 14) and a control group (n = 14). Pilates training was performed three 60-min sessions during 12 weeks. In two stages, blood samples were collected 48 hours before and after the last protocol exercise training session. During the 12 weeks, the control group had no exercise training. For analyzing within- and between-group changes, paired t-test and ANCOVA with the significant level of P < 0.05 were used, respectively. Results: After 12 weeks of Pilates training in the training group compared to the control group, there was a significant decrease in the body mass index (P = 0.005), cholesterol (P = 0.001) and triglyceride (P = 0.001) values, and serum 25-hydroxy vitamin D levels (P = 0.005), while high-density lipoprotein (P = 0.028) increased significantly. However, no significant change was observed in low-density lipoprotein levels (P = 0.435). Conclusions: According to the results, it can be indicated that 12 weeks of Pilates training have improved serum 25-hydroxy vitamin D levels, changed anthropometry, and lipid profile in inactive overweight women.
Aims: Hemostasis and serum levels of adipokines in the body are affected by physical activity and overweight. The present study investigates the effect of the Pilates exercise program on serum levels of resistin, visfatin, and chemerin in overweight women Methods & Materials: In this quasi-experimental study, 28 women with overweight voluntarily participated and were randomly divided into two groups of exercise (n=14) and control (n=14). The Pilates exercise program was presented to the exercise group for 8 weeks, 3 sessions per week, while the control group performed no exercise. Blood samples were taken before the intervention and 48 hours after the intervention in a fasting state to measure the serum levels of resistin, visfatin, and chemerin. The t-test was used for intra-group comparison and ANCOVA for inter-group comparison of the variables. The obtained data were analyzed in SPSS v. 23, considering a significance level of P<0.05 Findings: After 8 weeks of Pilates exercise, serum levels of resistin (P=0.001), visfatin (P=0.045), and chemerin (P=0.009) decreased significantly compared to pre-test values. A significant reduction in serum levels of resistin (P=0.005), visfatin (P=0.034), and chemerin (P=0.025) were also reported compared to the control group Conclusion: It seems that Pilates exercise can reduce resistin, visfatin, and chemerin levels in overweight women and can be considered as an appropriate exercise program to control the health and physiological conditions of overweight women
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