The objective of the study was to determine whether weight loss in obese men improves their fertility with respect to DNA fragmentation index and morphology. Collected fertility parameters included DFI and morphology. Body mass index (BMI) was calculated for all patients with comparisons to their fertility parameters before and after weight loss using paired t test and chi-square tests. The mean BMI was significantly higher in group 1, before weight loss (33.18 kg/m ), than in group 2, after weight loss (30.43 kg/m ). Overall, 53.3% of men had DFI <20% while 43.8% had a DFI between 20% and 40%, and 2.9% of men had DFI >40%. The mean DFI of participants was higher before weight loss (20.2%) and had improved significantly after weight loss (17.5%) (p = <.001). The weight loss had significant positive correlation with percentage of DFI. There was a significant improvement in morphology after weight loss (p = <.05). In one of the largest cohorts of male fertility and obesity, DFI and morphology demonstrated significant relationship with adiposity, possibly contributing to subfertility in this population.

Objective To determine whether weight loss in obese men improves seminal parameters. Design Prospective interventional study. Setting Infertility clinic and weight loss centers. Patient All men attending infertility center and weight loss programmes from April 2012 to May 2015 (n = 105). Intervention Diet counseling and exercise. Main Outcome Measure Collected reproductive parameters included semen analysis (ejaculate volume, sperm concentration, progressive and non-progressive motility) data. Body mass index (BMI) was calculated for all patients with comparisons to reproductive parameters before and after weight loss by using paired-t test and Chi-square tests. Result The mean BMI was significantly higher before weight loss (33.2) than after weight loss (30.4) in obese men. The weight loss had significant positive correlation with percentage of progressive sperm motility (p = < 0.001) and static percentage (p = < 0.001). Weight loss had non-significant correlation with semen volume (p = 0.083), concentration (p = 0.418) and non progressive motile sperm (p = 0.361). Conclusion In one of the largest cohorts of male fertility and obesity, semen parameters demonstrated mild but significant relationships with BMI and semen parameters, possibly contributing to subfertility in this population. How to cite this article Jaffar M, Ashraf M. Does Weight Loss improve Fertility with respect to Semen Parameters—Results from a Large Cohort Study. Int J Infertil Fetal Med 2017;8(1): 12-17.

Aim: To investigate role of AdipoR1 concentrations and leptin levels in obese and healthy subjects along with their lipid status Methods: This cross sectional study was conducted in residents of Sialkot city and included 132 subjects. Each group had 66 participants. Mean age was 39.6±0.97 years. Mean BMI for obese subjects was 31.55±0.6 while healthy group BMI was 20.5±0.2. Individuals with known history of diabetes, hypertension, chronic kidney disease, any malignancy and history of lipid lowering, antihypertensive, antipsychotics and antiepileptic were excluded. Fasting blood samples were taken after informed and written consent. Samples were centrifuged to extract serum and stored for analysis by ELISA method for AdiopR1 and leptin while lipid profile was determined by kits by Randox Diagnostics using micro lab. Data was analyzed by SPSS v. 26. Comparison between groups was carried out by Mann-Whitney U test. Results: Our study revealed higher levels of serum AdipoR1 (28.9±22.86 ng/mL), leptin (320.7±59.38 pg/mL), cholesterol (216±5.31 mg/dl), triglyceride (177.8±4.93 mg/dl) and LDL (139.3±4.56 mg/dl) in obese when compared with healthy individuals, AdiopoR1 (17.8±1.96ng/mL), leptin (219±20.76 pg/mL), cholesterol (179.8±3.25 mg/dl), triglyceride (149.8±3.17mg/dl), LDL (108.5±25.7 mg/dl) respectively. No statistical difference was found for HDL between groups. Conclusion: Our Study concludes that rising levels of AdipoR1 and leptin in addition to lipid profile are associated with obesity. Keywords: Obesity, Receptor Proteins AdipoR1, Leptin, lipid status, adipose tissue