Does Weight Loss improve Fertility with respect to Semen Parameters—Results from a Large Cohort Study

Jaffar, Mir; Ashraf, Mohammed

doi:10.5005/jp-journals-10016-1141

Cited by 10 publications

(8 citation statements)

References 48 publications

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“…115 Therefore additional studies are needed to draw strong conclusions in this area. 56,116,117 It is noteworthy that the extent to which semen parameter improvements associated with weight loss are accompanied by concomitant improvements in reproductive potential need to be further studied because most infertile men have normal sperm quality. However, considering the increasing prevalence of obesity and decreasing male fertility, it is suggested that clinicians should have increased awareness of the effects of obesity on fertility and the underlying mechanisms in order to appropriately counsel patients and provide more effective treatments.…”

Section: Discussionmentioning

confidence: 99%

Male adiposity, sperm parameters and reproductive hormones: An updated systematic review and collaborative meta‐analysis

et al. 2020

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Summary The present updated systematic review and meta‐analysis aims to summarize the evidence from published studies with low risk for any important bias (based on methodological quality assessment) investigating the potential associations of adiposity with sperm quality and reproductive hormones. We conducted a systematic search of the literature published in MEDLINE‐PubMed and EMBASE through June 2019. Based on the criteria in our review, 169 eligible publications were used for data abstraction. Finally, 60 articles were included in the qualitative analysis and 28 in the quantitative analysis. Our systematic review results indicated that overweight and/or obesity were associated with low semen quality parameters (i.e., semen volume, sperm count and concentration, sperm vitality and normal morphology) and some specific reproductive hormones (e.g., inhibin B, total testosterone and sex hormone‐binding globulin). Overweight and/or obesity were also positively associated with high estradiol concentrations. Meta‐analysis indicated that overweight and/or obesity categories were associated with lower sperm quality (i.e., semen volume, sperm count and concentration, sperm vitality, total motility and normal morphology), and underweight category was likewise associated with low sperm normal morphology. In conclusion, our results suggest that maintaining a healthy body weight is important for increasing sperm quality parameters and potentially male fertility.

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Section: Discussionmentioning

confidence: 99%

Male adiposity, sperm parameters and reproductive hormones: An updated systematic review and collaborative meta‐analysis

et al. 2020

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“…[24] Jaffar, in 2016, showed that weight loss had significant positive correlation with the percentage of progressive motile sperm and percentage of static sperm. [25] A recent meta-analysis by Macdonald et al suggested that no association exists between BMI and seminal parameters. [26] Aghamohammadi et al, in 2014, concluded that there was no statistical correlation between BMI and sperm concentration, sperm motility, sperm morphology, or ejaculate volume.…”

Section: Discussionmentioning

confidence: 99%

Association between male body mass index and semen parameters

Puri¹,

Sharma²,

Gaur³

et al. 2020

IJMS

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Objective: Obesity is a modern-day epidemic. Body mass index (BMI) is an easily computed surrogate marker of obesity. The incidence of obesity has paralleled the incidence of male infertility. The evidence of the association between BMI and semen parameters stays rather inconclusive. The aim of this study was to understand the association between BMI and semen parameters of male subjects evaluated at the infertility clinic. Materials and Methods: A prospective study was conducted on 410 male subjects (>18 years of age) who were referred to clinical pathology from the infertility clinic. Semen analysis for macroscopic parameters – total sperm concentration, motility, morphology, and viability, was done as per the guidelines laid by the WHO (WHO-5th edition 2010). Results: All the semen parameters showed higher aberrations in the obese group than the normal BMI group. However, on Pearson Chi-square analysis, none of these differences were found to be statistically significant (P > 0.05). On Pearson correlation analysis, none of the parameters showed a statistically significant correlation with BMI. Conclusion: The present study did not find any statistically significant differences for the commonly measured semen parameters, among the three BMI groups. We thus conclude that increased BMI or obesity has no significant impact on the semen parameters.

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“…Furthermore, they found that testosterone treatment significantly attenuates inflammation progression, mediated by blocking the infiltration of inflammatory immune cells and promoting the expansion of competent CD4 + CD25 + Foxp3 + Tregs in testes (71,192,193). Furthermore, aromatase inhibitors increase testosterone in obese males and improve spermatogenesis and sperm quality; however, significant evidence-based studies on the management of male fertility remain lacking (182). Although the adequate concentration of testosterone is critical for spermatogenesis, excessive testosterone through testosterone therapy generally deteriorates fertility parameters in males via the negative feedback mechanism and should not be used as part of fertility management (182,194).…”

Section: Hormone Therapymentioning

confidence: 99%

Impacts of Immunometabolism on Male Reproduction

Huang

Liu

et al. 2021

Front. Immunol.

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The physiological process of male reproduction relies on the orchestration of neuroendocrine, immune, and energy metabolism. Spermatogenesis is controlled by the hypothalamic-pituitary-testicular (HPT) axis, which modulates the production of gonadal steroid hormones in the testes. The immune cells and cytokines in testes provide a protective microenvironment for the development and maturation of germ cells. The metabolic cellular responses and processes in testes provide energy production and biosynthetic precursors to regulate germ cell development and control testicular immunity and inflammation. The metabolism of immune cells is crucial for both inflammatory and anti-inflammatory responses, which supposes to affect the spermatogenesis in testes. In this review, the role of immunometabolism in male reproduction will be highlighted. Obesity, metabolic dysfunction, such as type 2 diabetes mellitus, are well documented to impact male fertility; thus, their impacts on the immune cells distributed in testes will also be discussed. Finally, the potential significance of the medicine targeting the specific metabolic intermediates or immune metabolism checkpoints to improve male reproduction will also be reassessed.

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Does Weight Loss improve Fertility with respect to Semen Parameters—Results from a Large Cohort Study

Cited by 10 publications

References 48 publications

Male adiposity, sperm parameters and reproductive hormones: An updated systematic review and collaborative meta‐analysis

Male adiposity, sperm parameters and reproductive hormones: An updated systematic review and collaborative meta‐analysis

Association between male body mass index and semen parameters

Impacts of Immunometabolism on Male Reproduction

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