Objectives: Cortical visual impairment is amongst the key pathological causes of pediatric visual abnormalities predominantly resulting from hypoxic-ischemic brain injury. Such an injury results in profound visual impairments which severely impairs patients' quality of life. Given the nature of the pathology, treatments are mostly limited to rehabilitation strategies such as transcranial electrical stimulation and visual rehabilitation therapy. Case description: Here, we discussed an 11 year-old girl case with cortical visual impairment who underwent concurrent visual rehabilitation therapy and transcranial electrical stimulation resulting in her improved visual function. Conclusions: This novel and noninvasive therapeutic intervention has shown potential for application in neuro-visual rehabilitation therapy (nVRT).
Purpose: With increasing breast cancer (BC) survival rates, the survivors' quality of life (QoL) has become an important issue. Chemotherapy-induced cognitive impairment, known as "chemobrain" has been addressed recently. Therefore, cognitive function as one of the determinants of QoL should be considered while prescribing chemotherapeutics. In this study, we aimed to evaluate the effects of two common chemotherapy regimens on BC survivors' cognition. Methods: The participants comprised 35 BC patients who underwent two common chemotherapy regimens, AC-T and TAC, and 24 matched healthy volunteers. The participants were assessed regarding anxiety, depression, general health status, and cognitive function including aspects of concentration, verbal ability, reasoning, memory, and visuospatial skill through Addenbrooke's Cognitive Examination (ACE-P) and Cambridge Brain Science (CBS) tests. Results: Regarding depression and anxiety, there were no significant differences between the three groups. However, BC patients significantly complained of chronic fatigue compared to healthy volunteers (P-value = 0.027). Besides, ACE-P revealed the language domain to be affected in the AC-T group in comparison with the TAC-treated cases (P-value = 0.036). Moreover, the patients receiving the AC-T regimen had worse performance in visuospatial working memory and attention domains compared to the TAC group considering CBS tests (P-value = 0.031 and 0.008, respectively).
Conclusion:The results represent the AC-T regimen to be more toxic than the TAC in domains of language, concentration, and visuospatial working memory.
Implications for cancer survivors:The AC-T regimen should be prescribed with caution in BC patients suffering from baseline cognitive impairments to improve post-chemotherapy QoL.
Introduction. Investigation of the crossover sign (COS) in different degrees of tilt in pelvises made by three-dimensional printing of CT scans among patients with normal hip versions was carried out. Methods. Radiology CT scans of 8 normal pelvises reconstructed in 3D and the effect of sequential tilting on the presence of the false-positive COS in 48 radiographs were investigated. Results. The COS was seen in 77% of the AP radiographs during tilt changes. The average distance between the tip of the coccyx and the symphysis pubis was 32.06 ± 10.99 mm. Also, COSs were present in all radiographs from 6 degrees tilt and above. Conclusion. Minor tilting of the pelvis can result in a false-positive crossover sign on AP plain radiographs.
PurposeWith increasing breast cancer (BC) survival rates, the survivors’ quality of life (QoL) has become an important issue. Chemotherapy-induced cognitive impairment, known as “chemobrain” has been addressed recently. Therefore, cognitive function as one of the determinants of QoL should be considered while prescribing chemotherapeutics. In this study, we aimed to evaluate the effects of two common chemotherapy regimens on BC survivors’ cognition.MethodsThe participants comprised 35 BC patients who underwent two common chemotherapy regimens, AC-T and TAC, and 24 matched healthy volunteers. The participants were assessed regarding anxiety, depression, general health status, and cognitive function including aspects of concentration, verbal ability, reasoning, memory, and visuospatial skill through Addenbrooke’s Cognitive Examination (ACE-P) and Cambridge Brain Science (CBS) tests.ResultsRegarding depression and anxiety, there were no significant differences between the three groups. However, BC patients significantly complained of chronic fatigue compared to healthy volunteers (P-value = 0.027). Besides, ACE-P revealed the language domain to be affected in the AC-T group in comparison with the TAC-treated cases (P-value = 0.036). Moreover, the patients receiving the AC-T regimen had worse performance in visuospatial working memory and attention domains compared to the TAC group considering CBS tests (P-value = 0.031 and 0.008, respectively).ConclusionThe results represent the AC-T regimen to be more toxic than the TAC in domains of language, concentration, and visuospatial working memory.Implications for cancer survivorsThe AC-T regimen should be prescribed with caution in BC patients suffering from baseline cognitive impairments to improve post-chemotherapy QoL.Graphical Abstract
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