Background:The ischemic preconditioning phenomenon can save myocardium against move severe ischemic damages and reduce infarction size and furthermore a heart rhythm disturbance. In this study we examine relationship between troponin I (as a structural myocardial protein) level and anesthetic agents in the children.Materials and Methods:In this study 84 children under 12 years age before cardiac surgery were divided randomly into two groups of 42 each. For anesthetic maintenance sevoflurane with dose of 0.5-1 MAC was used in Group 1 and 100-150 mg/kg/min of intravenous propofol in Group 2 for maintenance of anesthesia. Troponin I level was assessed 2 before and 1 hour after anesthetic induction. Outcome measures included the serum cardiac troponin I level in children before and after surgery in two study groups.Results:There was no significant difference between two groups in indices and both groups were homogenous in this point of view. The troponin I level after surgery was significantly increased in two groups. In the sevoflurane group it was 0.04 ± 0.12 to 0.05 ± 0.09 ng/ml (P value = 0.003) and the propofol group was 0.12 ± 0.26 to 0.19 ± 0.38 ng/ml (P value = 0.001).Conclusions:In this study two Anesthetic regimens were compared to assess the mean troponin I level before and after pediatric closed heart surgery, and it was shown that mean troponin level before and after surgery in the sevoflurane group was less than the propofol group. But this result was not statistically significant. These results indicate that although more protective effects of sevoflurane on myocardial injuries during pediatric cardiac surgery is predominant but this effect has no significant difference in the propofol group.
The aim of this study was evaluating the effect of running training (RT)
on brain-derived neurotrophic factor (BDNF) and its receptor TrKB, glial
fibrillary acidic protein (GFAP), dark neurons and thickness of CA1 and
dentate gyrus (DG), corticosterone and spatial memory performance in
adult male rats exposed to chronic stress. Adult male wistar rats were
randomly assigned to five groups: RT; exposure to chronic mild stress
(CS); exposure to chronic mild stress followed by running training, (CS
+ RT), (CS + Recovery); control group. Findings indicated that the
lowest expression of GFAP, number of dark neurons and corticosterone
level, the highest thickness of CA1, DG, BDNF and TrKB and spatial
memory performance were observed in the RT group. In the CS + RT group,
expression of GFAP, the number of dark neurons and corticosterone level
were lower, while thickness of CA1 and DG, BDNF, TrKB and spatial memory
performance were higher compared to control and CS + Recovery. In the CS
group, the expression of GFAP, the number of dark neurons and
corticosterone level were highest and thickness of CA1 and DG, BDNF,
TrKB and spatial memory performance were lowest among the study groups.
In the CS + Recovery group, the expression of GFAP, the number of dark
neurons and corticosterone level were lower, compared to the CS group.
The study revealed that running training could attenuate the expression
of GFAP, the number of dark neurons, corticosterone level and improve
stress-induced reduction of BDNF, TrKB and spatial memory.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.