This study aims to estimate the prevalence and longevity of detectable SARS-CoV-2 antibodies and T and B memory cells after recovery. In addition, the prevalence of COVID-19 reinfection and the preventive efficacy of previous infection with SARS-CoV-2 were investigated. A synthesis of existing research was conducted. The Cochrane Library, the China Academic Journals Full Text Database, PubMed, and Scopus, and preprint servers were searched for studies conducted between 1 January 2020 to 1 April 2021. Included studies were assessed for methodological quality and pooled estimates of relevant outcomes were obtained in a meta-analysis using a bias adjusted synthesis method. Proportions were synthesized with the Freeman-Tukey double arcsine transformation and binary outcomes using the odds ratio (OR). Heterogeneity was assessed using the I 2 and Cochran's Q statistics and publication bias was assessed using Doi plots. Fifty-four studies from 18 countries, with around 12,000,000 individuals, followed up to 8 months after recovery, were included. At 6-8 months after recovery, the prevalence of SARS-CoV-2 specific immunological memory remained high; IgG -90.4% (95%CI 72.2-99.9, I 2 = 89.0%), CD4+ -91.7% (95%CI 78.2-97.1y), and memory B cells 80.6% (95%CI 65.0-90.2) and the pooled prevalence of reinfection was 0.2% (95%CI 0.0-0.7, I 2 = 98.8). Individuals previously infected with SARS-CoV-2 had an 81% reduction in odds of a reinfection (OR 0.19, 95% CI 0.1-0.3, I 2 = 90.5%). Around 90% of recovered individuals had evidence of immunological memory to SARS-CoV-2, at 6-8 months after recovery and had a low risk of reinfection.Registration PROSPERO: CRD42020201234

Objectives This study aims to estimate the prevalence and longevity of detectable SARS-CoV-2 antibodies as well as T and B memory cells during infection with SARS-CoV-2 and after recovery. In addition, prevalence of COVID-19 reinfection, and the preventive efficacy of previous infection with SARS-CoV-2 were investigated. Methods and analyses A synthesis of existing research was conducted. The Cochrane Library for COVID-19 resources, the China Academic Journals Full Text Database, PubMed, and Scopus as well as preprint servers were searched for studies conducted between 1 January 2020 to 1 April 2021. We included studies with the relevant outcomes of interest. All included studies were assessed for methodological quality and pooled estimates of relevant outcomes were obtained in a meta-analysis using a bias adjusted synthesis method. Proportions were synthesized with the Freeman-Tukey double arcsine transformation and binary outcomes using the odds ratio (OR). Heterogeneity between included studies was assessed using the I2 and Cochrans Q statistics and publication bias was assessed using Doi plots. Results Fifty-four studies, from 18 countries, with a total of 12 011 447 individuals, followed up to 8 months after recovery were included. At 6-8 months after recovery, the prevalence of SARS-CoV-2 specific immunological memory remained high; IgG 90.4% (95%CI 72.2 to 99.9, I2=89.0%, 5 studies), CD4+ 91.7% (95%CI 78.2 to 97.1, one study), and memory B cells 80.6% (95%CI 65.0 to 90.2, one study) and the pooled prevalence of reinfection was 0.2% (95%CI 0.0 to 0.7, I2 = 98.8, 9 studies). Individuals previously infected with SARS-CoV-2 had an 81% reduction in odds of a reinfection (OR 0.19, 95% CI 0.1 to 0.3, I2 = 90.5%, 5 studies). Conclusion Around 90% of people previously infected with SARS-CoV-2 had evidence of immunological memory to SARS-CoV-2, which was sustained for at least 6-8 months after recovery, and had a low risk of reinfection.

Introduction: Retinal diseases especially those due to diabetes and AMD are coming up as important causes of blindness and visual impairment. Our study is to evaluate the frequency and pattern of retinal diseases in ophthalmic outpatient department of a district hospital in Bangladesh. Materials and Methods: A total number of 173 referred new retina cases were reviewed at outpatient department of the 250 beded General Hospital, Jamalpur, Bangladesh, between February 2017 and November 2017. Data was analyzed according to age, sex and clinical diagnoses and detailed fundus evaluation done with binocular indirect ophthalmoscope and slit lamp using 20D and 90D lenses respectively. Results: Out of 7164 new patients,of whom 173 patients were (2.42%) presented with retinal diseases.139 patients were reviewed and followed up. Male: female ratio was 1.24:1. Out of 139 patients 77 (55.4%) were males and 62 (44.6%) females with a peak age group of 41-50 years. Diabeticrelated retinal conditions were 36 cases (25.9%), the most common cause.16 (44.44% of total DR) patients had CSME and 5(14.9%) had ADED. Diabetic retinopathy 36 cases (25.9%), Chorioretinitis 20 cases (14.4%), ARMD 11 cases (7.9%), and Optic atrophy 10 cases (7.2%). Conclusion: Retinal diseases remain an important cause of visual morbidity. There is increasing incidence of retinal blindness especially diabetic retinopathy in Bangladesh. The impression based on hospital practice is that the problem is increasing. This entails the necessity for accessible comprehensive eye care services, establishment of human resources, screening and awareness of the disease and affordable eye health policy. Medicine Today 2020 Vol.32(1): 1-4

Background: Dyspepsia is a common gastrointestinal problems affecting all age groups & social classes. Objectives: The purpose of the study was to determine the endoscopic findings of dyspeptic patients & to observe the demographic characteristics (age, sex, residence, education, socioeconomic condition) of the patients presented with dyspepsia. Methodology: This was a cross-sectional study conducted at Department of Medicine, Rangpur Medical College Hospital, Rangpur over a period of 1 year from 1st June 2010 to 31st May 2011. 150 dyspeptic patients of 18 or > 18 years old irrespective of sexes and suffering from one or more of the five symptoms (flatulence, food intolerance, epigastric pain, heartburn and aerophagia) for at least 6 months duration were recruited for the study from outpatient and inpatient department who were met the inclusion & exclusion criteria. Data were collected by using a structured questionnaire after taking written consent & upper GI Endocopy were done following meticulous history & through physical examination. Result: Over one-third (36%) of the patients were below 30 years, 17% between 30 – 40 years old, predominantly were rural residents, having primary to secondary level of education with monthly income below Taka 10000. Males to females ratio were 2:1. More than half (50.6%) of the patients was smoker, 32.7% had habit of taking tea, 10% were tobacco chewing and rest 6.7% used to take spicy meal.. Epigastric discomfort, flatulence and heartburn were the common complaints in both male and females but vomiting were proportionately higher in male dyspeptics compared to the female dyspeptics. Common associated symptoms like constipation and weight loss were equally in both sexes. Upper GI endoscopy revealed 17.3% of male and 11.5% of female with abnormal findings.Others abnormal findings included gastric ulcer, gastritis and duodenal ulcers (17.6 vs. 33.3%; 23.6 vs. 50% and 17.6 vs. 16.7% in male and female respectively). Majority (nearly 90% in either sex) of patients does not show any lesions on endoscopic examination and hence can be considered as non-ulcer dyspepsia. Conclusion: The study concludes that majority of patients with complaints of dyspepsia have no lesion on the gastric or duodenal mucosa and can be considered non-ulcer dyspepsia. The study findings also suggest that dyspepsia is a disease of young and early middle aged people with males being more likely to develop the disease than the females. However, large-scale community survey is recommended for further evaluation of dyspepsia. J Shaheed Suhrawardy Med Coll, December 2020, Vol.12(1); 9-14