Introduction: Obsessive-compulsive disorder is a chronic psychological disorder that causes serious damage to the mental, emotional and communication health of patients. Aim:The aim of this study was to evaluate the effectiveness of acceptance and commitment therapy (ACT), on distress tolerance and the severity of obsessive-compulsive disorder (OCD).Method: This study was designed using a Quasi-experimental method and pre-test, post-test as and control group. The study population included all patients referred to the psychiatric ward of Mostafa Khomeini Hospital in Dorood between 2018 and 2019. For this purpose, 20 patients with OCD were selected by convenience sampling and assigned to two groups of ACT and control. Each group was tested before and after the intervention by the Yale-Brown scale and the distress tolerance questionnaire (DTQ). The experimental group received 8 sessions of treatment based on ACT and the control group was not subjected to therapy. Data were analyzed by multivariate analysis of covariance (MANCOVA) through SPSS Statistics 24 and presented by descriptive and inferential statistics. Results:The results suggest that ACT had a significant statistical effect on reducing OCD symptoms (P= 0.000, F= 92.503) and increasing distress tolerance (P= 0/000, F= 33.889). Its effect on the obsession and distress tolerance variables was 87.7% and 72.3%, respectively. Conclusion:Considering the therapeutic elements of ACT and its coordination with the psychological problems of OCD, it can be a suitable therapy for these patients.
10.30699/jambs.30.141.319 Background & Objective: Selective serotonin reuptake inhibitors (SSRIs) and tricyclic antidepressants are utilized for treatment of post stroke depression, reduced quality of life and poor compliance. This study compared the effects of sertraline and nortriptyline on the quality of life and depression in post-stroke patients. Materials & Methods: This randomized double-blind trial was conducted on 56 stroke patients admitted to Valiasr Hospital in Zanjan, Iran, 2016. Patients were randomly allocated in two groups by simple randomization and received sertraline in one group, nortriptyline in the other and nobody received placebo. Patients were screened for depression using BDI (II) questionnaire and those without depression were entered into study. During follow-up, patients completed a quality of life questionnaire named Nottingham Health Profile (NHP). Data were analysed using repeated measure and Bonferroni tests in SPSS 22. P<0.05 was considered statistically significant. Results:The mean age of patients in sertraline and nortriptyline groups were 61.7 and 63.6, respectively (P=0.194). No significant differences were observed for sex, marital status and education between two groups. The mean score of total quality of life and its dimensions decreased significantly during 6 months for both groups (P=0.001). The effect of sertraline in these reductions was not different from nortriptyline (P=0.60). The proportions of moderate or severe depression were 17.9% and 37.0% in sertraline and nortriptyline groups, respectively (P=0.24). Conclusion:Both sertraline and nortriptyline improved all aspects of quality of life and their effect on prevention of depression was similar. Therefore, the administration of sertraline or nortriptyline could be beneficial in post-stroke patients.
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