The one-pot three-component reactions of 1,3-dimethylbarbituric acid, aromatic aldehydes and alkyl or aryl isocyanides proceed smoothly at room temperature to give the corresponding 5-aryl-6-alkyl or arylamino-1,3dimethylfuro[2,3-d]pyrimidine-2,4(1H,3H )-dione derivatives in good to excellent yields within 30 minutes in DMF. This three-component reaction represents a facile and efficient route to the described biologically interesting molecules.
A Simple and Convenient Approach to the Synthesis of Aminofuropyrimidinediones. -A facile and efficient route to the title furopyrimidinediones (17 examples), compounds of potential synthetic and biological interest, is given using one-pot three-component reactions of dimethylbarbituric acid with aromatic aldehydes and isocyanides. Scope and limitations of the methodology are studied. -(SHAABANI*, A.; TEIMOURI, M. B.; AFGHEH, M.; ESKANDARI, M.; J. Chem. Res. 35 (2011) 1, 37-42, http://dx.doi.org/10.3184/174751911x556765 ; Dep. Chem., Shahid Beheshti Univ., Tehran, Iran; Eng.) -K. Wilckens 23-150
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