Print) 2090-5076 (Online) Journal homepage: https://www.tandfonline.com/loi/tajm20 Study of urinary interferon gamma-induced protein 10 (IP-10) and urinary soluble CD 25 (sCD25) as markers of lupus nephritis and their relation to histological class (2018) Study of urinary interferon gamma-induced protein 10 (IP-10) and urinary soluble CD 25 (sCD25) as markers of lupus nephritis and their relation to histological class, Alexandria Journal of Medicine, 54:4, 647-653, a b s t r a c t Objective: To study the role of urinary interferon gamma-induced protein 10 (IP-10) and urinary soluble CD 25 (sCD 25) as diagnostic and prognostic markers of lupus nephritis (LN) and their relation to the LN class in renal biopsy. Subjects and methods: This study included 45 lupus patients fulfilling the Systemic Lupus International Collaborating Clinics (SLICC) classification criteria: 25 patients with active LN during activity and during follow up (3 months later) as [group A] and 20 patients without any signs of activity [group B]. (20) age and sex matched healthy subjects were enrolled as control group [group C]. Urine samples were collected at baseline and at follow up. Urinary IP-10 and sCD25 were measured by ELISA.Results: Urinary IP-10 and sCD25 levels were higher in group A compared to groups B and C (P < 0.001 for both). In patients with active nephritis, urinary IP-10 and sCD25 correlated positively with serum creatinine (P < 0.001 for both), proteinuria (p = 0.010; p = 0.007), anti ds-DNA (p = 0.002; p < 0.001), SLEDAI score (global) (P < 0.001 for both), and renal SLEDAI score (p = 0.002; p < 0.001) respectively. The urinary IP-10 and sCD25 levels were highest in patients with class (IV) LN and lowest in class (II) patients with a statistically significant difference. In patients achieving remission with treatment, both markers decreased significantly. Conclusion: Urinary IP-10 and sCD25 are potential biomarkers for early recognition and follow up of LN. Ó 2018 Alexandria University Faculty of Medicine. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Purpose: To document the effects of successful vitrectomy on retinal function and anatomy in diabetic patients. Methods: Three-port pars plana vitrectomy with detachment of posterior vitrous face was performed in 30 eyes of 25 patients with diabetic macular oedema DME (11 male, 14 Female).For each patients, visual acuity (VA) examination, measurement of retinal thickness using optical coherence tomography (OCT), full field electro-retinogram (ERG) and multifocal eletroretinogram (MF-ERG) were performed before and 1week,1month and 3months after vitrectomy. Results: Mean postoperative visual acuity was significantly improved (P<0.05); mean retinal thickness was significantly (P=0.001 ) decreased after 3monthes of surgery (from 450±150 into 220±50 micron ) .b-wave amplitudes of all cone and rod responses of ERG were significantly decreased in all vitrectomized eyes after 1 week. At one month, rod response was still unimproved but improved after 3months. Reduction in foveal Function as well as in para-foveal areas detected in the MF-ERG within 1st month. Then, mean P1 wave amplitude of MF-ERG of central ring increased and mean P1 wave implicit time decreased. These changes of MF-ERG parameters observed 3 months after vitrectomy. Conclusion: Multifocal electroretinogram can be useful to provide objective criteria for functional evaluation before and after vitrectomy in diabetic oedema.
Background: Laparoscopic Sleeve Gastrectomy (LSG) has become one of the commonest bariatric procedures done for management of obese patients. Although Laparoscopic Roux-en-Y Gastric Bypass (LRYGB) has well documented positive clinical influence on type 2 diabetes, the role of LSG in diabetes treatment is still questionable. In this study we want to present our experience in management of diabetes with LSG.Methods: Between September 2014 and June 2016, fifty patients were enrolled in our prospective study at Department of Surgery, Ain Shams University assessing the effect of LSG on morbid obese patients with Type 2 Diabetes Mellitus (T2DM). All patients were monitored for weight loss and improvement of T2DM markers; Fasting Blood Glucose (FBG), Postprandial Plasma Glucose (PPG) and HbA1c at 3, 6 and 12 months follow-up post-operative.Results: There was a highly significant difference between BMI at baseline and at 12 months after operation, resolution of type 2 diabetes mellitus occurred in 70% of patients evident by normalization of HbA1 c (5.6%) and stopping all medications, and improvement occurred in 10% of patients evident by HbA1c value of 6.5% without medication.Conclusion: Laparoscopic sleeve gastrectomy is simple and effective surgical procedure to achieve a significant weight loss and control of type 2 diabetes mellitus which starts in the early post-operative period. There is significant reduction in the diabetes medications hence the cost of diabetes treatment and improvement of the quality of life.
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