Introduction: Street sweepers play an important role in maintaining the health and hygiene in the communities. However, their job exposes them to various hazards while, little or no attention is paid to their health status. Aim of the work: To study the possible work-related morbidities among street sweepers and waste collectors emphasizing on the occupational risks they are exposed to and the preventive measures they take to avoid their job-related hazardous exposures. Materials and Methods: A total of 138 street sweepers and waste collectors and a matching control group of randomly selected 127 university workers and clerks were interviewed, answered the study questionnaire, and had medical examination, then they offered blood and stool samples for laboratory investigations. Results: Compared to the control group, street sweepers and waste collectors had significantly higher rates of HCV seropositivity, parasitic infestations, skin irritation, respiratory complaints and work-related injuries; but with significantly lower mean hemoglobin levels, (p<0.05). However, no significant difference was detected for HBV infection, eye complaints, joint or lower back pains. Most of street sweepers had never been medically examined, vaccinated, trained for safety practices or even health educated regarding their occupation-related health hazards. Conclusion: Street sweeping and waste collection