Microwave‐assisted treatment of ethyl 5‐hydroxy‐1‐phenyl‐1H‐pyrazole‐4‐carboxylate with excess primary aliphatic amines in 1‐propanol at 140°C and with excess pyrrolidine or piperidine in 2‐methoxyethanol at 180°C produced the corresponding carboxamides in good yields.
Microwave-Assisted Direct Amidation of Ethyl 1-Phenyl-5-hydroxy-1H-pyrazole--4-carboxylate. -A simple microwave-assisted direct amidation of the title carboxylate (I) is reported which is limited to primary aliphatic amines and most reactive cyclic secondary amines, such as pyrrolidine and piperidine. -(MILOSEVIC, M.; STERBAL, I.; FEGUS, U.; BASKOVC, J.; PREK, B.; GROSELJ, U.; STANOVNIK, B.; SVETE*, J.; J. Heterocycl. Chem. 52 (2015) 2, 556-561, http://dx.
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