Microwave‐Assisted Direct Amidation of Ethyl 1‐Phenyl‐5‐hydroxy‐1H‐pyrazole‐4‐carboxylate

Abstract

Microwave‐assisted treatment of ethyl 5‐hydroxy‐1‐phenyl‐1H‐pyrazole‐4‐carboxylate with excess primary aliphatic amines in 1‐propanol at 140°C and with excess pyrrolidine or piperidine in 2‐methoxyethanol at 180°C produced the corresponding carboxamides in good yields.

Fast microwave-assisted conjugation of magnetic nanoparticles with carboxylates of biological interest

“…Traditional processes 7,16 perform amidation reaction on the Fe 3 O 4 -NP surface at 37 C overnight with DMSO as solvent. Here we propose a fast method, adapted from the literature, [17][18][19] using microwave heating (P ¼ 400 W) and MeOH/H 2 O as solvent at 120 C. All experiments reached 4 bar of pressure in 15 minutes of reaction. Size distribution of different Fe 3 O 4 -NP was analyzed by TEM ( Fig.…”