One important aspect in the application of dual phase (DP) steels in the automotive industry are their weldability and subsequent mechanical properties. Welding involves a rapid change in the temperature which alters the microstructure and the mechanical properties of the steel. Understanding the influence of welding conditions on the mechanical properties of DP 600 is useful for both the automotive industry and steel producers. Despite its importance, the weldability study of dual phase steels is still limited. In this paper the microstructural evolution and its influence on the mechanical properties of 1 mm thick zinc coated DP 600 steel are described for laser beam welding (LBW) and plasma arc welding (PAW) processes. Microstructural and mechanical characterisation were performed using optical microscopy, microhardness measurements, tensile tests and Erichsen cupping tests. The process comparison shows differences in the final mechanical properties resulting from the microstructural differences in the welding zones.
The treatment for high-grade glioma remains an enigma. The standard treatment using surgery, radiation therapy and chemotherapy for such highly malignant lesions has only yielded modest results, in terms of survival and improving the quality of life of patients. Less than 10% of such patients survive beyond two years. All conventional therapies have failed to increase the survival beyond this extent. There has been a growing interest in the molecular approaches for the treatment of high-grade gliomas which include gene therapy, oncolytic virotherapy, and immunotherapy. These new therapies are in preclinical and investigational stages. They may not substitute the conventional therapies; they may not be the ultimate elixir for this deadly disease. However, in the coming years, they are likely to have synergistic and complimentary roles alongside conventional therapies. Through this paper, we have attempted to highlight the rationale behind gene therapy which can be used for cytotoxic approaches, immunomodulation strategy, and targeted toxin delivery in the tumor cell. We have reviewed current available literature and through this paper focus on reporting such therapeutic options, their potential usage, benefits and limitations.
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