Design Prospective study. Purpose To evaluate real-time duplex colour Doppler examination with colour and pulse Doppler ultrasonography (US) (colour Doppler imaging (CDI)) for detection of the retinal detachment from membranous structures in the posterior segment. Materials and methods In 33 consecutive patients with ophthalmoscopically invisible eyes (34 eyes), CDI was performed to detect the presence or absence of retinal detachment. The diagnostic criterion for retinal detachment was whether or not spectral waveforms were detected in membranous structures with colour and pulse Doppler US. In all cases, the absence or presence of retinal detachment was confirmed by surgery. Results In 27 of 34 eyes, membranes and/or opacities were observed in the vitreous cavity with CDI. In 12 of these 27 eyes, blood flow in those structures was detected by CDI. In all of these 12 eyes, retinal detachment was confirmed at surgery, and in 14 of the 15 eyes in which blood flow was not detected by CDI, absence of retinal detachment was confirmed at surgery. When a diagnosis confirmed by surgery was used as the definitive finding, CDI had a sensitivity of 92.3%, specificity of 100%, positive predictive value of 100%, negative predictive value of 93.3%, and an accuracy in the detection of retinal detachment from membranes and/or opacities in the vitreous cavity of 96.3%. Conclusion Real-time duplex colour Doppler examination with colour and pulse Doppler US (CDI) is a noninvasive method useful for the detection of retinal detachment from vitreous opacity and/or membrane in the posterior segment.

A 50-year-old highly myopic Asian man had loss of vision in the left eye for 4 months. Visual acuity was 20/30 in the right eye and 20/40 in the left eye. Funduscopy disclosed a tilted disk, a large oval depression located in the region of the myopic conus ( Fig. 1), and a contiguous, transparent elevation of the macula in the left eye. No myopic staphyloma was noted. StratusOCT (Carl Zeiss Meditec, Dublin, CA) scans (Figs. 2 and 3) showed interruption of the hyperreflective band corresponding to the scleral tissue in the central region of the oval depression, along with signs of two distinct communications between the deeper spaces at the base of the anomaly and the neurosensory retina. One of the communica-The authors have no proprietary interest in the development or marketing of the device (or any competing device) mentioned in this report. Reprint requests: Fabio B. Aggio, MD, Alameda Jaú, 150 ap 21 B., Fig. 2. A, Ultrasonographic examination of the right eye (at initial presentation) showing a choroidal lesion surrounded by subretinal fluid. B, Marked increase in the size of the lesion depicted in A 2 months later.

Purpose. To investigate the effects of nipradilol on retrobulbar hemodynamics. Methods. We investigated normal and normal-tension glaucoma (NTG) eyes. Topical nipradilol (one eye) and placebo eye drops (fellow eye) were instilled for 1 week in volunteers. Nipradilol was also instilled in NTG patients. Ultrasound color Doppler imaging for the posterior vessels was performed before, 2 hr, 1 week (for normal), and at 4 weeks (for NTG). Results. In normal eyes, there were significant decreases in the resistance index (RI) for the temporal short posterior ciliary arteries (PCA) at 2 hr and for the ophthalmic arteries at 1 week. There were no significant changes in the placebo-treated eyes. In the NTG eyes, there was a significant decrease in the RI for the central retinal artery, nasal, and temporal PCA at 2 hr and 4 weeks. Conclusion. Short-term observations found that nipradilol increased the ocular blood flow in normal and NTG eyes.