Triamcinolone Acetonide Remaining on the Fovea After Successful Macular Hole Closure

Abstract

A 50-year-old highly myopic Asian man had loss of vision in the left eye for 4 months. Visual acuity was 20/30 in the right eye and 20/40 in the left eye. Funduscopy disclosed a tilted disk, a large oval depression located in the region of the myopic conus ( Fig. 1), and a contiguous, transparent elevation of the macula in the left eye. No myopic staphyloma was noted. StratusOCT (Carl Zeiss Meditec, Dublin, CA) scans (Figs. 2 and 3) showed interruption of the hyperreflective band corresponding to the scleral tissue in the central region of the oval depression, along with signs of two distinct communications between the deeper spaces at the base of the anomaly and the neurosensory retina. One of the communica-The authors have no proprietary interest in the development or marketing of the device (or any competing device) mentioned in this report. Reprint requests: Fabio B. Aggio, MD, Alameda Jaú, 150 ap 21 B., Fig. 2. A, Ultrasonographic examination of the right eye (at initial presentation) showing a choroidal lesion surrounded by subretinal fluid. B, Marked increase in the size of the lesion depicted in A 2 months later.

Comparative evaluation of anatomical and functional outcomes using brilliant blue G versus triamcinolone assisted ILM peeling in macular hole surgery in Indian population

“…However, we did not find any significant difference in hole closure between the two dyes. Other reports have also shown that residual TA in MHS does not seem to interfere with anatomic or visual improvement [49,50].…”

Macular Hole Closure With Triamcinolone-Assisted Internal Limiting Membrane Peeling

“…32,33 There have been anecdotal case reports that have described persistence of TA in the macular hole after vitrectomy surgery but no long-term study has evaluated final outcomes. 34,35 In this article, we report the anatomic and visual outcomes of macular hole surgery with triamcinoloneassisted ILM peeling.…”

Subretinal injection of preservative-free triamcinolone acetonide and supernatant vehicle in rabbits: an electron microscopy study

“…For chromovitrectomy, the white steroid may be injected intraoperatively to aid in the observation of the transparent vitreous gel as well as for ILM-peeling in macular hole surgery [2,3]. However, during chromovitrectomy some amount of TA may penetrate through the macular hole, thereby migrating into the subretinal space [22,23]. For retinal drug delivery, subretinal TA-infusion may provide high choroidal drug concentrations for the therapy of angiogenic and edematous chorioretinal diseases [11].…”