Background: The chemotherapeutic use of cisplatin (CP) is restricted because of its hepatotoxicity induced by oxidative stress. Malondialdehyde (MDA) is a secondary product of lipid peroxidation as a biomarker of oxidative stress. Individual administration of black seed oil (BSO) or honey (H) demonstrated hepatoprotective effect in rats. Interaction of both substances when administrated as combination can be evaluated using combination index (CI) to quantitatively depict synergism (CI<1), additive (CI=1) and antagonism effect (CI>1). Objective: to know the combination effect of BSO and honey on rat liver tissue given CP exposure. Methods: This study used 30 rats were divided into 10 groups. Normal group (N); Negative control group (NC); P1-P4 groups were administerated BSO (1 and 2 mL/kg) and honey (3.7 and 7.4 mL/kg); P5-P8 groups were combination of BSO and H. P1-P8 groups were given BSO and honey orally for 21 days. On the 18th day, NC and P1-P8 groups were given CP 8 mg/kg intraperitoneally, while the N group was given NaCl 0.9% 1 mL/kg intraperitoneally. Result: Malondialdehyde (MDA) levels were found to be lower in P1-P8 groups compared to negative control group and P6 and P7 groups have levels equivalent to MDA levels of normal control group (p > 0.05). Conclusion: Combination of BSO and honey provides a protective effect on cisplatin-induced rat liver tissue damage indicated by reduced MDA levels, but all combination group showed antagonism effect.
The purpose of this study was to develop a learning video media to increase the knowledge of clean and healthy living in kindergarten children in group B. This research conducted in three kindergartens in Banten Province, namely TK Al Aziz - Tangerang, TK Al Kautsar - Serang and Raudhatul Jannah - Cilegon. This research took place from January 2017 to June 2019. This research used the J. Moonen prototype development model. Learning evaluation is carried out in stages, namely expert reviews consisting of learning design experts, material experts, and instructional media experts. After reviewing from experts, I continued with one to one trials, small group trials, and field tests for kindergarten B group children. Based on the trial, the results of the development were obtained, which proved that learning video products are suitable for media use in improving knowledge of the clean and healthy life of children. The novelty of this research is to produce an appropriate and exciting healthy living behavior (HLB) Learning Media Video for teachers to use in conducting teaching and learning activities in schools, which consists of 4 episodes of HLB at the end of each episode reinforced by an expert reviewing the core of each chapter and also equipped with music as an introduction.
<p>Prevalensi presbikusis sebesar 30-35% di antara orang berusia 65-75 tahun di Indonesia. Presbikusis mengganggu komunikasi dan memengaruhi kualitas hidup penderitanya. Tujuan penelitian ini untuk mengetahui hubungan antara gangguan pendengaran dan kualitas hidup penderita presbikusis di RSUD Sultan Syarif Mohamad Alkadrie Kota Pontianak. Penelitian analitik dilakukan dengan pendekatan potong lintang. Subjek penelitian berjumlah 39 orang. Kualitas hidup pada penelitian ini diukur dengan kuesioner HHIE-S <em>(Hearing Handicap Inventory for the Elderly-Screening)</em>. Analisis data dengan uji <em>Kendall’s tau c</em> menunjukkan <em>p value </em>= 0,0000 dan nilai korelasi sebesar 0,675. Terdapat korelasi kuat antara gangguan pendengaran dan kualitas hidup penderita presbikusis di RSUD Sultan Syarif Mohamad Alkadrie Pontianak tahun 2019.</p><p> </p><p>The prevalence of presbycusis among 65-75 year-olds in Indonesia is 30-35%. Presbycusis will reduce their communication ability and impact their quality of life. This study aimed to determine the correlation between degree of hearing loss and quality of life among presbycusis patients at RSUD Sultan Syarif Mohamad Alkadrie. Thirty nine subjects were included in this analytical cross-sectional study. The quality of life was measured using the HHIE-S (Hearing Handicap Inventory for the Elderly-Screening) questionnaire. Kendall’s tau c analysis resulted in p value = 0.0000 and correlation coefficient was 0.675. Severity of hearing loss is strongly related to quality of life among presbycusis patients at RSUD Sultan Syarif Mohamad Alkadrie in Pontianak in 2019.<strong></strong></p>
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