Different benzaldehydes and pyridine substitution were used on 1 and 4 'N'-positions of thiosemicarbazide respectively. This substituted-benzaldehyde-2-aminopyridine-N-thiohydrazone ligand was further used to synthesize Co(II), Ni(II) and Co(II) based metal complexes and characterized by FT-IR, Elemental analysis, ESI Mass and elemental analysis. All synthesized compounds were studied for their physical properties, antibacterial and antifungal activity. In this antimicrobial study Cu(II) and Ni(II) metal complexes have shown better anti-bacterial activity. While several synthesized metal complexes have shown comparable activity with standard drugs taken.
In search of some antimicrobial agents, synthesis of some Schiff base of cyanoacetohydrazide derivatives has been reported. The structures of all the synthesized compounds were established on the bases of various spectroscopic methods. All Schiff base were screened for antimicrobial activity. cyanoacetohydrazide were found to possess better antimicrobial potential.
The title Schiff base compound, C14H10Cl2N2O, features an E configuration about each of the C=N imine bonds. Overall, the molecule is approximately planar with the dihedral angle between the central C2N2 residue (r.m.s. deviation = 0.0371 Å) and the peripheral hydroxybenzene and chlorobenzene rings being 4.9 (3) and 7.5 (3)°, respectively. Nevertheless, a small twist is evident about the central N—N bond [the C—N—N—C torsion angle = −172.7 (2)°]. An intramolecular hydroxy-O—H...N(imine) hydrogen bond closes an S(6) loop. In the crystal, π–π stacking interactions between hydroxy- and chlorobenzene rings [inter-centroid separation = 3.6939 (13) Å] lead to a helical supramolecular chain propagating along the b-axis direction; the chains pack without directional interactions between them. The calculated Hirshfeld surfaces point to the importance of H...H and Cl...H/H...Cl contacts to the overall surface, each contributing approximately 29% of all contacts. However, of these only Cl...H contacts occur at separations less than the sum of the van der Waals radii. The aforementioned π–π stacking interactions contribute 12.0% to the overall surface contacts. The calculation of the interaction energies in the crystal indicates significant contributions from the dispersion term.
ABSTRACT1,5-benzodiazepines have been synthesized by Nano Zirconia and Nano Sulfated Zirconia in solvent free conditions. Synthesis was carried out by conventional as well as microwave method. Benzodiazepines were synthesized by reacting o-phenylenediamine and few ketones in the presence of catalytic amount of Nanoparticles. Particles used were sized in between 53-100 nm. Nanoparticles were characterized by FT-IR, DLS and powder XRD analysis.
A series of resins was synthesized and analyzed for selective ion-exchange nature for some metals. Substituted aniline was reacted with formaldehyde, melamine. For the synthesis of ionexchange resins, sulfuric acid was used as a catalyst. These resins were characterized by elemental analysis and studied antimicrobial activities. Synthesized Resin shows ion exchange capability and moderate activity against microbial. Ion exchange resin also showed reusability and stability at an elevated temperature.
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