Synthesis, Spectral Analysis and Evolution of Antimicrobial Activity of Schiff Base of Cyanoacetohydrazide

Jadeja, Juvansinh J.; Mamtora, Mayank J.; Gondaliya, Mitesh B.; Manawar, Rohit B.; Shah, Manish K.

doi:10.56431/p-mrpq1z

Cited by 2 publications

(4 citation statements)

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“…The 13 C NMR spectrum of the ligand (Figure S3) showed a signal at 57.6 ppm related to the methylene group. The signal of the methyl carbons connected to para ‐substituted phenyl and azomethine carbons was observed at 24.3 and 20.6 ppm, respectively 56 . The signals at 113.4, 126.8, 129.9, and 144.6 ppm were described as the para ‐substituted phenyl ring carbons 57 .…”

Section: Resultsmentioning

confidence: 95%

“…The thiophene ring carbons appeared at 127.2, 128.5, and 130 ppm 58,59 . The signal of the azomethine carbon was observed at 155 ppm 56 . The chemical shift at 173 ppm could be assigned to the carbonyl group.…”

Section: Resultsmentioning

confidence: 95%

“…The signal of the methyl carbons connected to para-substituted phenyl and azomethine carbons was observed at 24.3 and 20.6 ppm, respectively. 56 The signals at 113.4, 126.8, 129.9, and 144.6 ppm were described as…”

Section: H and 13 C Nmr Spectramentioning

confidence: 99%

“…58,59 The signal of the azomethine carbon was observed at 155 ppm. 56 The chemical shift at 173 ppm could be assigned to the carbonyl group.…”

Section: H and 13 C Nmr Spectramentioning

confidence: 99%

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Antibacterial, antifungal, and anticancer screening of some nano mono Co(II), Zn(II), Ru(III), and Ag(I) binuclear metal complexes of new hydrazone ligand

Hassan,

Rizk,

Khidr

et al. 2023

Applied Organom Chemis

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A new series of Co(II), Zn(II), Ru(III), and Ag(I) complexes with the ligand (Z)‐N′‐(1‐(thiophen‐2‐yl)ethylidene)‐2‐(p‐tolylamino)acetohydrazide (H2L) has been prepared. FT‐IR, 1H‐NMR, electronic spectra, powder X‐ray, and thermal behavior were applied to elucidate the structural composition of new compounds. The electronic spectra proved that the Co(II), Zn(II), and Ru(III) complexes possess tetrahedral geometry, except the Ag(I) complex is a binuclear complex. The mass spectrum of the Zn(II) and Ag(I) chelates and the molecular ion peak observed at m/z values equivalent to the calculated molecular weight confirmed the proposed structure. Also, the SEM scanning electron microscope technique explored the spherical shape of all chelates, and the nanoscale was confirmed through TEM; the transmission electron microscope tool that provided the 7.0 nm was achieved in the case of Zn(II) chelate. Geometry optimization for all synthesized compounds was estimated by density functional theory (DFT) method using the Gaussian09 program. Biological screening as an antimicrobial and antitumor was studied. The Ru(III) complex revealed the greatest antibacterial efficiency, followed by the Co(II) complex. Co(II) complex revealed a greater affinity against fungi such as Candida albicans and Aspergillus niger. All chelate‐induced antitumor effects against the MCF‐7 cell line, especially Ag(I) complex (IC50 = 62.36 μg/mL), exhibited the greatest efficiency. The activity sequence follows the order doxorubicin (standard drugs) > Ag(I) > Zn(II) > ligand < Ru(III) > Co(III) chelates. The molecular docking was performed and validated to support the biological results.

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Section: Resultsmentioning

confidence: 95%

Section: Resultsmentioning

confidence: 95%

Section: H and 13 C Nmr Spectramentioning

confidence: 99%

“…58,59 The signal of the azomethine carbon was observed at 155 ppm. 56 The chemical shift at 173 ppm could be assigned to the carbonyl group.…”

Section: H and 13 C Nmr Spectramentioning

confidence: 99%

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