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and Kerala. [4] All ages and both sexes were affected. [4] The disease is characterized by acute fever with or without chills, headache, nausea, abdominal pain, photophobia, conjunctival injection, skin rash, and disabling arthralgia. The incubation period ranges between 2 and 10 days. The disease usually affects adults as seen in the 2006 epidemic: of the 333 seropositive patients for chikungunya infection, 299 (90%) were aged older than 15 years. [5] Chikungunya originated from the word "kungunyala" (meaning "that which bends up"). The patient with this disease develops a stooped posture because of severe arthritis, typically affecting the wrists, hands, ankles, and feet. The fever and skin rash are short-lasting, but the joint pains may recur or linger for a long Background: Chikungunya is viral fever with the main symptom of joints pain for prolong duration. It persists as major public health problem till date. Objective: To know the seroprevalence, clinical presentation, and seasonal trends of chikungunya infection in a tertiary-care hospital in Ahmedabad, Gujarat, India. Materials and Methods: A retrospective observational study was conducted at a tertiary-care hospital in Ahmedabad. Totally, 2193 blood samples were received from different wards from suspected cases of chikungunya fever and tested for IgM antibody using ELISA in civil hospital Ahmedabad for duration of 1 year (September 2013 to August 2014). Result: Of the 2193 cases tested, 724 (33.01%) were positive for IgM antibodies; 33.28% were aged younger than 30 years and 66.71% older than 30 years. All presented with fever (100%), followed by joint pain, headache, body ache, joint swelling, and rash (93.6%, 73%, 39.7%, and 17.4%, respectively). Maximum cases were reported during September to January (31.98%, 35%, 36.41%, 43.34%, and 42.18%, respectively), with male subjects of 41.02% and female subjects, 58.97%. Conclusion: Seroprevalence of chikungunya in our study (33.01%), which was high in late monsoon and winter, suggests that it continues to be a major health problem in our setup and indicates the need of appropriate strategies to reduce the severity of disease.

Introduction: Thrombocytopenia is not a disease but is a diagnosis. The detailed knowledge must be acquired from patients who have thrombocytopenia. This study aimed to determine the relative frequency of different disease conditions presenting as newly found thrombocytopenia in adult patients and to determine whether a low platelet count or presence of bleeding manifestation was considered more often as an indicator for platelet transfusion. Materials and Methods: This retrospective study was done at a tertiary care hospital during the period of November 2018 to October 2019. Blood samples were analyzed for Complete Blood Count (CBC). The clinicopathological correlation was done and the findings were tabulated. Results: In present study, the sex distribution of patients of thrombocytopenia was noted as 55.75% male and 44.25% female. The present study showed that most of the cases of thrombocytopenia belonged to the age group of 18-29 years (45%), followed by the age group of 30-39 years (28.75%), the least being in the age group of over 80 years (2.0%). Most of the patients presented with Grade 1 thrombocytopenia (49.5%). The most common etiology responsible for newly diagnosed thrombocytopenia in adult patients was found to be dengue/dengue-like fever (41.75%). Conclusion: It can be concluded from this study that the most common causes for thrombocytopenia are infective causes e.g. dengue, malaria.

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