Background and Aim: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) rapid emergence postured significant challenges on the health system in recent years. The early detection of cases is thought to be critical in preventing this pandemic by coronavirus disease (COVID-19), especially important in the obstetrical population due to theirs numerous interactions with another parturient when hospitalized for delivery. Therefore, the present study aimed to assess the COVID antigen test performance in COVID-positive obstetrics patients. Materials and Methods: This cross-sectional study was conducted on 1296 Covid-19 asymptomatic women admitted to the Obstetrics and Gynaecology Department of Muhammad Teaching Hospital & Medical College, Peshawar and Fauji Foundation Hospital, Rawalpindi for the duration of six months from February 2021 to July 2021. Antigen-based test rapid diagnostic test (RDT) was used for screening out COVID-19 positive obstetrics patients or women through nasopharyngeal swabs. Women with negative rapid antigen test results were confirmed with RT-polymers chain reaction test of nucleic acid amplification tests (NAAT). Ethical approval and informed consent were taken from the hospital ethical committee and each individual respectively. All the known positive COVID-19 patients during admission were excluded. SPSS version 24 was used for data analysis. Results: The overall prevalence of rapid antigen-positive tested patients was 13.2% (171/1296). The prevalence of positive tested women through rapid antigen test, Nucleic Acid Amplification Test (NAAT), and RT-PCR were 27 (2.1%), 51 (3.9%), and 93 (7.2%) respectively. Of the total 1296 rapid antigen tests, 27 were positive, and the false-negative confirmed positive by NAAT was 144.Thus the sensitivity of the rapid antigen test was 15.8% and the negative predictive value was 93.7%. Of the total 298 Nucleic Acid Amplification Tested had sensitivity and negative predictive value of 89.6% and 99.06% respectively. RT-PCR was carried out on 972 patients, positive diagnosed cases were 36 while 15 were initially negative and were positive with the test was repeated. The sensitivity and negative predictive value was 71.45% and 95.8% respectively. Conclusion: Our study found that Ag-RDT plays a significant role in SARS-CoV-2 early detection in infected individuals, with high specificity and sensitivity to disease infectious stage, whether symptomatic or asymptomatic, and can be used as a decision supported tool. Early detection of COVID-19 status in women admitted for delivery could benefit neonatal protection care. Keywords: Covid-19; Rapid antigen test; RT-PCR test
Background: The Covid-19 pandemic has wreaked havoc throughout the world, with 150 million cases to date and over 3 million lives claimed worldwide. Aim: To explored the difference in levels of SaO2 of COVID-19 positive patients with and without COPD. Study design: Experimental Study. Methodology: From May2020 to 2021 patients admitted at Aziz Bhatti Shaheed hospital were included in this studies. COVID-19 was confirmed by RT-PCR.COPD was confirmed by using GOLD standard of diagnostic criteria. SaO2 was measured by using pulse oximeter and confirmed by blood samples measurement of SaO2. Statistical analysis: SPSS version 22 was used for data analysis. Paired sample t test was performed to evaluate the hypoxia levels between three pairs among the time distribution of 1st, 3rd, and 6th, day. Results: Levels of SaO2 were statistically significant between COVID-19 positive patients and COVID-19 positive patients with COPD. We calculated the levels of SaO2 at day1, 3rd, and 6th day and results were significant to show that COPD might be having some protective effect against hypoxia and that might be due to use of medications or adaptation of pulmonary cells. Conclusion: It was concluded that levels of SaO2 was significantly reduced in COVID-19 patients without COPD in comparison to patients without COPD. Keywords: COVID-19, COPD and SaO2.
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