A study was conducted to measure residues of 13 organophosphorus (OP) pesticides, widely used as dairy cattle ectoparasiticides or in crops used for animal feed, in homogenized and pasteurized Mexican milk samples. Four different milk brands with high distribution were collected biweekly during a 12 month period (n = 96) in supermarkets. OP pesticide residues were measured by gas chromatography with a flame photometric detector. Approximately 39.6% of the samples contained detectable levels of OP pesticide residues. Eight samples contained residues exceeding established maximum residue limits (MRL), and the OP pesticides present in these samples were dichlorvos (five samples), phorate, chlorpyrifos, and chlorfenvinphos (one sample, respectively). Average residues of 13 OP pesticides measured were below established MRLs ranging between 0.0051 and 0.0203 ppm.

These results support the use of anti-sulfated glycosaminoglycan antibody-based immunotherapy as a potential tool to prevent atherosclerosis.

SummaryA reference database comprising body weight gain, exploratory activity, hot plate response, serum biochemistry, haematology, organ weight (%) and a complete anatomopathological study containing non-neoplastic and neoplastic lesions over 1200 Sprague-Dawley rats from 6 to 32 months is described. Comparisons between age and sex were analysed.Keywords Database; Sprague-Dawley rats, biological parameters Toxicology laboratories and other research institutions collect large bodies of reference data in order to support drug and chemical toxicity testing. However, many of these databases contain either a relatively small number of animals, a limited number of parameters, or poorly defined limitations by age, all of which limit their usefulness on a routine basis. In addition, it is often unclear whether the same test method was used throughout the data collection period. In our laboratory, we have set up and maintain a large reference database. The database covers not only the main physiological indicators, including results of the anatomicopathological studies, but also the major life span of this species. The data were classified into three main age groups, <6,6-18 and 18-32 months according to Wolford et a1. (1986), and sex. The present results correspond to data of special sentinel groups from different preclinical toxicological evaluations performed in our laboratory during the last 7 years.

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Administration of D-004 resulted in marked and significant prevention of phenylephrine-induced impairment of micturition and histological changes in rat prostate. These findings indicate that, in vivo, D-004 effectively opposes these responses to phenylephrine, which are mediated through urogenital alpha(1)-adrenoceptors. In this respect, D-004 was moderately more effective than Saw palmetto, a phytotherapeutic standard used to treat BPH, but less effective than tamsulosin, a selective alpha(1A)-adrenoceptor antagonist.

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