Although the roots of molecularly imprinted polymers lie in the beginning of 1930s in the past century, they have had an exponential growth only 40–50 years later by the works of Wulff and especially by Mosbach. More recently, it was also proved that molecular imprinted membranes (i.e., polymer thin films) that show recognition properties at molecular level of the template molecule are used in their formation. Different procedures and potential application in separation processes and catalysis are reported. The influences of different parameters on the discrimination abilities are also discussed.
An atmospheric pressure plasma deposition for P(d,L)LA (PLA) film was used to modify polymer surface properties using 1,2‐diaminopropane and acrylic acid as precursors. These two different plasma coatings result in a high density of amino groups (PLA‐NH2) and carboxylic groups (PLA‐COOH) onto PLA surface as demonstrated by Fourier transform infra‐red (FTIR) spectroscopy and X‐ray photoelectron spectroscopy (XPS). Plasma coatings modified PLA surface wettability and proteins adsorption from fetal bovine serum (FBS), influencing cell adhesion and proliferation of 3T3 mouse fibroblast, MC‐3T3 E1 mouse pre‐osteoblast, and HaCaT cells (human keratinocytes). In particular both coatings increased pre‐osteoblast and keratinocyte adhesion while no effect was observed on fibroblast. Moreover, cell proliferation assessed after 48 h by Tox‐8 assay was significantly higher for osteoblast cells and keratinocyte seeded onto both PLA‐NH2 and PLA‐COOH compared to cells seeded onto normal PLA. On the basis of the obtained data, the atmospheric pressure plasma deposition described might represent an innovative and useful tool for bone and skin tissue engineering.
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